Comparison of axillary lymph nodes on breast MRI before and after COVID-19 booster vaccination Journal Article
| Authors: | Parikh, R.; Feigin, K. N.; Sevilimedu, V.; Huayanay, J.; Pinker, K.; Horvat, J. V. |
| Article Title: | Comparison of axillary lymph nodes on breast MRI before and after COVID-19 booster vaccination |
| Abstract: | Rationale and Objectives: Vaccine-related lymphadenopathy is a frequent finding following initial coronavirus disease 2019 (COVID-19) vaccination, but the frequency after COVID-19 booster vaccination is still unknown. In this study we compare axillary lymph node morphology on breast MRI before and after COVID-19 booster vaccination. Materials and Methods: This retrospective, single-center, IRB-approved study included patients who underwent breast MRI between October 2021 and December 2021 after the COVID-19 booster vaccination. The axillary lymph node with the greatest cortical thickness ipsilateral to the side of vaccination was measured on MRI after booster vaccination and before initial COVID-19 vaccination. Comparisons were made between patients with and without increase in cortical thickness of ≥ 0.2 cm. Continuous covariates were compared using Wilcoxon rank-sum test and categorical covariates were compared using Fisher's exact test. Multiple comparison adjustment was made using the Benjamini–Hochberg procedure. Results: All 128 patients were included. Twenty-four of 128 (19%) displayed an increase in lymph node cortical thickness of ≥ 0.2 cm. Patients who received the booster more recently were more likely to present cortical thickening, with a median of 9 days (IQR 5, 20) vs. 36 days (IQR 18, 59) (p < 0.001). Age (p = 0.5) and type of vaccine (p = 0.7) were not associated with thickening. No ipsilateral breast cancer or malignant lymphadenopathy were diagnosed on follow-up. Conclusion: Axillary lymphadenopathy on breast MRI following COVID-19 booster vaccination is a frequent finding, especially in the first 3 weeks after vaccination. Additional evaluation or follow-up may be omitted in patients with low concern for malignancy. © 2023 The Association of University Radiologists |
| Keywords: | magnetic resonance imaging; breast neoplasms; lymphadenopathy; vaccines; pandemic |
| Journal Title: | Academic Radiology |
| Volume: | 31 |
| Issue: | 3 |
| ISSN: | 1076-6332 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2024-03-01 |
| Start Page: | 755 |
| End Page: | 760 |
| Language: | English |
| DOI: | 10.1016/j.acra.2023.03.012 |
| PUBMED: | 37037711 |
| PROVIDER: | scopus |
| PMCID: | PMC10017388 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK authors: Joao V. Horvat -- Source: Scopus |
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