Characterization of the use and efficacy of isavuconazonium sulfate in a pediatric oncology and stem cell transplant population: A single institution retrospective review Journal Article
| Authors: | Kunvarjee, B.; Siver, M.; Mathew, S.; Steiger, S.; Lee, Y. J.; Spitzer, B. |
| Article Title: | Characterization of the use and efficacy of isavuconazonium sulfate in a pediatric oncology and stem cell transplant population: A single institution retrospective review |
| Abstract: | Isavuconazonium sulfate (ISA) is a triazole antifungal approved for the treatment of invasive aspergillosis and mucormycosis in adults. This single-center, retrospective review of pediatric oncology and stem cell transplant patients receiving ISA for prophylaxis (n=20) or treatment (n=6) of invasive fungal disease (IFD) aims to characterize real-world clinical efficacy and toxicity of ISA in patients <18 years of age. Of 20 patients receiving ISA for prophylaxis, three patients had presumed breakthrough IFD (1 proven, 2 probable/possible). No adverse effects were attributed to ISA use or led to the discontinuation of therapy. © 2024 Lippincott Williams and Wilkins. All rights reserved. |
| Keywords: | adolescent; adult; child; clinical article; retrospective studies; human cell; prednisone; neutropenia; drug efficacy; pyridines; drug megadose; neoplasm; neoplasms; computer assisted tomography; liver toxicity; neutrophil count; cohort analysis; antifungal agent; stem cell transplantation; chronic myeloid leukemia; oncology; retrospective study; acute lymphoblastic leukemia; childhood cancer; pediatric; alanine aminotransferase; aspartate aminotransferase; hematologic malignancy; myelodysplastic syndrome; neuroblastoma; prophylaxis; lymphoma; graft versus host reaction; hematopoietic cell; disease duration; corticosteroid; immunosuppressive treatment; tacrolimus; mycosis; cyclosporine; antifungal agents; triazoles; nitriles; drug use; nitrile; triazole derivative; immunosuppressive agent; aplastic anemia; pyridine derivative; abatacept; lung nodule; systemic mycosis; acute myeloid leukemia; aspergillus flavus; candida parapsilosis; clavispora lusitaniae; ruxolitinib; ibrutinib; humans; human; male; female; article; invasive fungal infections; isavuconazole; isavuconazonium sulfate; isavuconazonium; fusarium proliferatum |
| Journal Title: | Journal of Pediatric Hematology/Oncology |
| Volume: | 46 |
| Issue: | 2 |
| ISSN: | 1077-4114 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2024-03-01 |
| Start Page: | e143 |
| End Page: | e146 |
| Language: | English |
| DOI: | 10.1097/mph.0000000000002812 |
| PUBMED: | 38237014 |
| PROVIDER: | scopus |
| PMCID: | PMC11881917 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK authors: Binni Kunvarjee -- Source: Scopus |
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