Genomic evolution shapes prostate cancer disease type Journal Article
| Authors: | Woodcock, D. J.; Sahli, A.; Teslo, R.; Bhandari, V.; Gruber, A. J.; Ziubroniewicz, A.; Gundem, G.; Xu, Y.; Butler, A.; Anokian, E.; Pope, B. J.; Jung, C. H.; Tarabichi, M.; Dentro, S. C.; Farmery, J. H. R.; CRUK ICGC Prostate Group; Van Loo, P.; Warren, A. Y.; Gnanapragasam, V.; Hamdy, F. C.; Bova, G. S.; Foster, C. S.; Neal, D. E.; Lu, Y. J.; Kote-Jarai, Z.; Fraser, M.; Bristow, R. G.; Boutros, P. C.; Costello, A. J.; Corcoran, N. M.; Hovens, C. M.; Massie, C. E.; Lynch, A. G.; Brewer, D. S.; Eeles, R. A.; Cooper, C. S.; Wedge, D. C. |
| Article Title: | Genomic evolution shapes prostate cancer disease type |
| Abstract: | The development of cancer is an evolutionary process involving the sequential acquisition of genetic alterations that disrupt normal biological processes, enabling tumor cells to rapidly proliferate and eventually invade and metastasize to other tissues. We investigated the genomic evolution of prostate cancer through the application of three separate classification methods, each designed to investigate a different aspect of tumor evolution. Integrating the results revealed the existence of two distinct types of prostate cancer that arise from divergent evolutionary trajectories, designated as the Canonical and Alternative evolutionary disease types. We therefore propose the evotype model for prostate cancer evolution wherein Alternative-evotype tumors diverge from those of the Canonical-evotype through the stochastic accumulation of genetic alterations associated with disruptions to androgen receptor DNA binding. Our model unifies many previous molecular observations, providing a powerful new framework to investigate prostate cancer disease progression. © 2024 The Authors |
| Keywords: | controlled study; human tissue; single nucleotide polymorphism; cancer growth; protein dna binding; gene frequency; prostate cancer; dna; molecular evolution; gene fusion; double stranded dna break; genome; androgen receptor; cancer tissue; cancer classification; copy number variation; cancer evolution; indel mutation; telomere length; chromothripsis; dna sequencing; human; male; article; restricted boltzmann machine; ordering; ar binding; evotype model; evotypes |
| Journal Title: | Cell Genomics |
| Volume: | 4 |
| Issue: | 3 |
| ISSN: | 2666-979X |
| Publisher: | Cell Press |
| Date Published: | 2024-03-13 |
| Start Page: | 100511 |
| Language: | English |
| DOI: | 10.1016/j.xgen.2024.100511 |
| PROVIDER: | scopus |
| PMCID: | PMC10943594 |
| PUBMED: | 38428419 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
