Ensuring successful biomarker studies in bladder preservation clinical trials for non-muscle invasive bladder cancer Guidelines
| Authors: | McConkey, D. J.; Baumann, B. C.; Greenberg, S. C.; DeGraff, D. J.; Delacroix, S. E.; Efstathiou, J. A.; Foster, J.; Groshen, S.; Kadel, E. E.; Khani, F.; Kim, W. Y.; Lerner, S. P.; Levin, T.; Liao, J. C.; Milowsky, M. I.; Meeks, J. J.; Miyamoto, D. T.; Mouw, K. W.; Pietzak, E. J.; Solit, D. B.; Sundi, D.; Tawab-Amiri, A.; West, P. J.; Wobker, S. E.; Wyatt, A. W.; Apolo, A. B.; Black, P. C. |
| Title: | Ensuring successful biomarker studies in bladder preservation clinical trials for non-muscle invasive bladder cancer |
| Abstract: | Recent technological advances have created new opportunities for performing biomarker studies within the National Cancer Institute’s (NCI’s) National Clinical Trials Network (NCTN) clinical trials. These new platforms yield more robust measurements when tissue and blood handling is optimized. At the same time, there is a strong interest in banking tissue and derivatives, such as DNA and RNA, for future biomarker studies using novel platforms that may emerge during the intervening time to trial completion. The NCI recently hosted a Clinical Trials Planning Meeting focused on two trial concepts for bladder preservation in patients with high-risk non-muscle invasive bladder cancer (NMIBC) and the correlative translational research to be integrated into these trials, where experts discussed prioritization for the use of patient samples, and a framework for best practices emerged. The overall goal of this meeting report is to summarize this discussion and to provide the working group’s recommendations for biospecimen handling for future bladder preservation studies. © 2024 – The authors. Published by IOS Press. |
| Keywords: | nuclear magnetic resonance imaging; biological marker; computer assisted tomography; diagnostic imaging; blood; urine; cancer tissue; tissue preservation; bladder; clinical trial (topic); microbiome; non muscle invasive bladder cancer; human; article; ffpe rna; plasma tumor dna; tissue banking; urine tumor dna |
| Journal Title: | Bladder Cancer |
| Volume: | 10 |
| Issue: | 1 |
| ISSN: | 2352-3727 |
| Publisher: | IOS Press |
| Date Published: | 2024-01-01 |
| Language: | English |
| DOI: | 10.3233/blc-230082 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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