Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors Journal Article

   


Authors: Francis, J. H.; Barker, C. A.; Canestraro, J.; Abramson, D. H.; Shoushtari, A. N.
Article Title: Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors
Abstract: Purpose: To report a case of metastatic uveal melanoma treated with immune checkpoint inhibition in which serial circulating tumor DNA (ctDNA) was assessed throughout treatment. Observations: A 33-year-old man was diagnosed with metastatic uveal melanoma and initially had progression of disease following hepatic embolization and nivolumab/ipilimumab. At the time, plasma ctDNA GNA11 and SF3B1 were measurable and repeat ctDNA showed increased variant allele frequency following further progression of disease on vorinostat. Following additional nivolumab/ipilimumab, radiographic response was noted and repeat ctDNA became undetectable and remained so at 27 months follow up. Conclusions and importance: Clearance of cell free DNA in metastatic uveal melanoma may be associated with radiographic response to immune checkpoint inhibitors. © 2024 The Authors
Keywords: adult; clinical article; human tissue; treatment response; somatic mutation; exon; histopathology; cancer recurrence; case report; hepatitis; cancer growth; follow up; gene; ipilimumab; gene frequency; wild type; radiation response; liver metastasis; immunotherapy; vorinostat; enucleation; external beam radiotherapy; peritoneum metastasis; adjuvant radiotherapy; liver biopsy; vitiligo; gna11 gene; clearance; immune checkpoint inhibitor; high throughput sequencing; nivolumab; transpupillary thermotherapy; human; male; article; circulating tumor dna; metastatic uveal melanoma; sf3b1 gene; cell free dna; immune checkpoint inhibition; artificial embolization
Journal Title: American Journal of Ophthalmology Case Reports
Volume: 34
ISSN: 2451-9936
Publisher: Elsevier Inc.  
Date Published: 2024-05-31
Start Page: 102021
Language: English
DOI: 10.1016/j.ajoc.2024.102021
PROVIDER: scopus
PMCID: PMC10912039
PUBMED: 38444640
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85186614769&doi=10.1016%2fj.ajoc.2024.102021&partnerID=40&md5=0bc26e0a9487c9213750fc13a4ec1555
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK authors: Jasmine H. Francis -- Source: Scopus
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MSK Authors
  1. Jasmine Helen Francis
    256 Francis
  2. David H Abramson
    389 Abramson
  3. Christopher Barker
    218 Barker
  4. Alexander Noor Shoushtari
    244 Shoushtari
  5. Julia Canestraro
    27 Canestraro
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