Cellular cutaneous epithelioid hemangioma harboring the rare GATA6::FOXO1 gene fusion Journal Article

   


Authors: Tepp, J. A.; Agaram, N. P.; Chang, J. C.; Linos, K.
Article Title: Cellular cutaneous epithelioid hemangioma harboring the rare GATA6::FOXO1 gene fusion
Abstract: Epithelioid hemangioma (EH) is a benign vascular tumor displaying diverse histomorphologies. Among these, one EH subtype comprises cellular sheets of atypical epithelioid cells, posing potential challenges in distinguishing it from malignant vascular lesions. In this case report, we present a cutaneous cellular EH that carries the rare GATA6::FOXO1 gene fusion, a recent discovery. Our aim is to provide an updated insight into the evolving knowledge of EHs while delving into the histologic and molecular characteristics of the primary differential diagnoses. © 2024 Lippincott Williams and Wilkins. All rights reserved.
Keywords: immunohistochemistry; adult; clinical article; genetics; case report; follow up; vascular neoplasms; cd34 antigen; computer assisted tomography; skin defect; diagnosis, differential; differential diagnosis; pathology; angiosarcoma; histology; punch biopsy; gene fusion; transcription factor erg; vascular tumor; lymphadenopathy; hemangioma; transcription factor fkhr; cd68 antigen; hemangioendothelioma, epithelioid; cell vacuole; transcription factor gata 6; gata6 transcription factor; multiplex polymerase chain reaction; skin hemangioma; epithelioid hemangioendothelioma; gata6 protein, human; kimura disease; angiolymphoid hyperplasia with eosinophilia; foxo1; humans; human; female; article; epithelioid hemangioma; gata6; platelet endothelial cell adhesion molecule 1; forkhead box protein o1; foxo1 protein, human; gata6 foxo1 gene fusion
Journal Title: American Journal of Dermatopathology
Volume: 46
Issue: 4
ISSN: 0193-1091
Publisher: Lippincott Williams & Wilkins  
Date Published: 2024-04-01
Start Page: 223
End Page: 227
Language: English
DOI: 10.1097/dad.0000000000002647
PUBMED: 38457669
PROVIDER: scopus
PMCID: PMC10947873
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85187960307&doi=10.1097%2fDAD.0000000000002647&partnerID=40&md5=0807a72a1295597f59741a6019d6192f
Notes: Article -- Source: Scopus
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MSK Authors
  1. Narasimhan P Agaram
    190 Agaram
  2. Konstantinos Linos
    53 Linos
  3. Jason Chih-Peng Chang
    133 Chang
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