Safety and tolerability of intravenous aprepitant and fosaprepitant in children with cancer: A retrospective, single-center review Journal Article

   


Authors: Kanukollu, S.; Spatz, K.; Lavery, J. A.; Bender, J. G.; Mauguen, A.; Mathew, S.
Article Title: Safety and tolerability of intravenous aprepitant and fosaprepitant in children with cancer: A retrospective, single-center review
Abstract: NK-1 receptor antagonists (NK1-RA) are key agents for chemotherapy-induced nausea and vomiting (CINV) prevention in patients receiving highly emetogenic chemotherapy. Current pediatric practice guidelines recommend the use of intravenous fosaprepitant or oral aprepitant. However, there are reports of hypersensitivity reactions with fosaprepitant due to polysorbate 80. Intravenous aprepitant does not contain polysorbate 80, but its use in pediatric patients has not been described. In this retrospective, single-center study, 106 pediatric patients received either fosaprepitant or intravenous aprepitant as part of their antiemetic regimen. Intravenous aprepitant was well tolerated and did not lead to any instances of hypersensitivity reactions requiring discontinuation. © 2024 Wiley Periodicals LLC.
Keywords: child; controlled study; side effect; practice guideline; retrospective study; antiemetic agent; antiemetics; drug therapy; adverse drug reaction; intravenous drug administration; aprepitant; oral drug administration; supportive care; prevention; fosaprepitant; chemotherapy induced nausea and vomiting; human; male; female; article; polysorbate 80; pediatric patient; cinv; special situation for pharmacovigilance
Journal Title: Pediatric Blood and Cancer
Volume: 71
Issue: 4
ISSN: 1545-5009
Publisher: Wiley Periodicals, Inc  
Date Published: 2024-04-01
Start Page: e30882
Language: English
DOI: 10.1002/pbc.30882
PUBMED: 38267822
PROVIDER: scopus
PMCID: PMC11114950
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183008036&doi=10.1002%2fpbc.30882&partnerID=40&md5=6a7c2a12e9ed86fab1364bdd8df79fff
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding MSK author is Srivarshini Kanukollu -- Source: Scopus
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MSK Authors
  1. Sherry Mathew
    19 Mathew
  2. Audrey Mauguen
    158 Mauguen
  3. Julia L Glade Bender
    86 Glade Bender
  4. Krisoula Horiates Spatz
    8 Horiates Spatz
  5. Jessica Ann Lavery
    80 Lavery
  6. Srivarshini Kanukollu
    1 Kanukollu
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