Case-based clinical guidance on dosing and management of the hepatic artery infusion chemotherapy pump Review

  


Authors: Rao, D.; Ellis, C. S.; Kemeny, N.; Cercek, A.
Review Title: Case-based clinical guidance on dosing and management of the hepatic artery infusion chemotherapy pump
Abstract: Hepatic artery infusion (HAI) delivers localized high-dose floxuridine directly to liver tumors through an implanted pump. While patients are undergoing active treatment, the pump is refilled with chemotherapy alternating with saline every 2 weeks using a specialized noncoring needle. Numerous clinical scenarios influence the dosing of floxuridine, which do not conform to the usual dose modification schema for systemic chemotherapy. This article aims to provide practical clinical management solutions to overcome the common challenges faced by oncologists in the real-world management of HAI pump therapy.
Keywords: liver neoplasms; antineoplastic agent; antineoplastic combined chemotherapy protocols; pathology; colorectal neoplasms; colorectal tumor; liver tumor; intraarterial drug administration; infusions, intra-arterial; floxuridine; hepatic artery; humans; human
Journal Title: JCO Oncology Practice
Volume: 20
Issue: 2
ISSN: 2688-1527
Publisher: American Society of Clinical Oncology  
Date Published: 2024-02-01
Start Page: 187
End Page: 194
Language: English
DOI: 10.1200/op.23.00374
PUBMED: 37883732
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185200972&doi=10.1200%2fOP.23.00374&partnerID=40&md5=5c3027a397088aa4a366067bc16a2f38
Notes: Source: Scopus
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MSK Authors
  1. Andrea Cercek Hanjis
    351 Cercek Hanjis
  2. Nancy Kemeny
    543 Kemeny
  3. Devika Rao
    7 Rao
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