Diffuse pleural mesothelioma: Advances in molecular pathogenesis, diagnosis, and treatment Review

  


Authors: Febres-Aldana, C. A.; Fanaroff, R.; Offin, M.; Zauderer, M. G.; Sauter, J. L.; Yang, S. R.; Ladanyi, M.
Review Title: Diffuse pleural mesothelioma: Advances in molecular pathogenesis, diagnosis, and treatment
Abstract: Diffuse pleural mesothelioma (DPM) is a highly aggressive malignant neoplasm arising from the mesothelial cells lining the pleural surfaces. While DPM is a well-recognized disease linked to asbestos exposure, recent advances have expanded our understanding of molecular pathogenesis and transformed our clinical practice. This comprehensive review explores the current concepts and emerging trends in DPM, including risk factors, pathobiology, histologic subtyping, and therapeutic management, with an emphasis on a multidisciplinary approach to this complex disease. Copyright © 2024 by the author(s).
Keywords: unclassified drug; review; interferon; nonhuman; outcome assessment; antineoplastic agent; protein function; cell proliferation; cytology; gene; gene expression; risk factors; gene function; pathology; brca1 protein; risk factor; histology; carcinogenesis; tumor suppressor gene; genomic instability; pleura mesothelioma; mesothelioma; mitosis rate; cyclin dependent kinase inhibitor 2a; cancer classification; protein structure; cancer morphology; sarcomatoid mesothelioma; chromosome 3p; cdkn2a; nf2 gene; gene structure; molecular pathology; nf2; asbestos; immune evasion; cyclin dependent kinase inhibitor 2b; pleural mesothelioma; bap1; epithelioid mesothelioma; experimental therapy; setd2; niraparib; setd2 gene; humans; human; talazoparib; biphasic mesothelioma; chimeric antigen receptor immunotherapy; pevonedistat; diffuse pleural mesothelioma; gavocabtagene autoleucel; mrtx1719; ag 270; amg193; iag 933; ik 930; risovalisib; tng908; tulmimetostat; vt3989; zen 3694
Journal Title: Annual Review of Pathology: Mechanisms of Disease
Volume: 19
ISSN: 1553-4006
Publisher: Annual Reviews  
Date Published: 2024-01-01
Start Page: 11
End Page: 42
Language: English
DOI: 10.1146/annurev-pathol-042420-092719
PUBMED: 37722697
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183460951&doi=10.1146%2fannurev-pathol-042420-092719&partnerID=40&md5=881a6c4d7101c8cfd4df9ce0bb0d030f
Notes: Review -- MSK corresponding authors are Soo-Ryum Yang and Marc Ladanyi -- Source: Scopus
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MSK Authors
  1. Marc Ladanyi
    1332 Ladanyi
  2. Marjorie G Zauderer
    189 Zauderer
  3. Michael David Offin
    172 Offin
  4. Jennifer Lynn Sauter
    129 Sauter
  5. Soo Ryum Yang
    81 Yang
  6. Christopher Antonio Febres Aldana
    28 Febres Aldana
  7. Rachel Elizabeth Fanaroff
    8 Fanaroff
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