Safety of duodenal endoscopic submucosal dissection for superficial non-ampullary duodenal epithelial tumor: A single-center study in the United States Journal Article


Authors: Koseki, M.; Nishimura, M.; Nammour, T.; Chin, K.; Nagao, S.; Beauvais, J. C.; Schattner, M. A.
Article Title: Safety of duodenal endoscopic submucosal dissection for superficial non-ampullary duodenal epithelial tumor: A single-center study in the United States
Abstract: Endoscopic submucosal dissection (ESD) of superficial non-ampullary duodenal epithelial tumors (SNADETs) is associated with a high rate of en bloc resection and low rate of recurrence. However, in the United States, SNADETs are predominantly managed using endoscopic mucosal resection (EMR) or surgery because the feasibility and safety of duodenal ESD have not yet been established. In this study, we analyzed the outcomes of duodenal ESD for SNADETs. This single-center retrospective study reviewed the data of patients who underwent ESD for SNADETs between June 2018 and August 2023. Baseline patient characteristics, histopathology of the resected lesions, adverse events, and recurrence rates were evaluated. The primary outcome measures were en bloc resection, complications, and recurrence rate. Thirty ESD procedures were performed on 24 patients. All 30 lesions were adenomas, with no cancerous lesions. The en bloc resection rate and R0 resection rates were both 53%. There were no cases of procedure-associated perforation. Post-ESD bleeding was observed in six cases. No ESD-related mortality was observed. The recurrence rate was 14% in 1 year follow up, and 28% the during all follow-up period. ESD is a safe option for SNADET in the United States; however further comparative studies are necessary to determine the optimal procedure for North American populations.
Keywords: tumors; diagnosis; efficacy; en bloc resection; endoscopic submucosal dissection; mucosal resection; villous tumors; superficial non-ampullary duodenal
Journal Title: Journal of Clinical Medicine
Volume: 13
Issue: 1
ISSN: 2077-0383
Publisher: MDPI  
Date Published: 2024-01-01
Start Page: 143
Language: English
ACCESSION: WOS:001140521000001
DOI: 10.3390/jcm13010143
PROVIDER: wos
PMCID: PMC10780121
PUBMED: 38202150
Notes: Article -- 143 -- Source: Wos
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Mark Schattner
    173 Schattner
  2. Kana Chin
    6 Chin
  3. Mako Koseki
    10 Koseki
  4. Sayaka Yanagi
    9 Yanagi