Very low-dose radiotherapy for extranodal marginal zone lymphoma of bronchus-associated lymphoid tissue Journal Article
| Authors: | Freret, M. E.; Tringale, K. R.; Boe, L.; Imber, B. S.; Joffe, E.; Yahalom, J.; Hajj, C. |
| Article Title: | Very low-dose radiotherapy for extranodal marginal zone lymphoma of bronchus-associated lymphoid tissue |
| Abstract: | Extranodal marginal zone lymphoma of bronchus-associated lymphoid tissue (BALT) is a rare cancer for which optimal treatment strategies are undefined. Retrospective analyses suggest excellent outcomes with surgical resection for localized BALT lymphoma; however, the role of radiotherapy remains underexplored. We report the largest-to-date single-center analysis of 13 primary BALT lymphoma patients treated with radiotherapy. Of 15 treated lesions, we report a 100% response rate with complete response (CR) achieved in 67% of lesions. Among 10 lesions treated with very low-dose radiotherapy (VLDRT; 4 Gray [Gy]), 6 (60%) achieved a CR; among 5 lesions treated with full-dose radiotherapy (24–36 Gy), 4 (80%) achieved a CR. There were no local recurrences. Only one patient, treated with 30 Gy, developed an acute grade 3/4 toxic effect. There were no events of radiation-induced secondary malignancies. Our institutional experience indicates that radiotherapy, including VLDRT, is a safe and effective treatment for primary BALT lymphoma. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | adult; treatment outcome; treatment response; aged; middle aged; retrospective studies; major clinical study; fatigue; cancer recurrence; cancer combination chemotherapy; rituximab; multiple cycle treatment; radiation; cohort analysis; bendamustine; pathology; retrospective study; active surveillance; bronchus; dermatitis; lymphoid tissue; lobectomy; marginal zone lymphoma; radiation sickness; bronchi; wedge resection; lymphoma, b-cell, marginal zone; low-grade lymphoma; low-dose radiotherapy; very elderly; humans; human; male; female; article; extranodal marginal zone lymphoma; balt lymphoma; pulmonary malt; very low-dose radiotherapy; bronchus associated lymphoid tissue extranodal marginal zone lymphoma |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 64 |
| Issue: | 13 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2023-01-01 |
| Start Page: | 2195 |
| End Page: | 2201 |
| Language: | English |
| DOI: | 10.1080/10428194.2023.2255706 |
| PUBMED: | 37706509 |
| PROVIDER: | scopus |
| PMCID: | PMC10962616 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Carla Hajj -- Source: Scopus |
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