Radiation oncology for the rhinologist Review
| Authors: | Levyn, H.; Yang, F.; Lee, N. Y. |
| Review Title: | Radiation oncology for the rhinologist |
| Abstract: | PURPOSE OF REVIEW: This comprehensive review explores evolving treatment strategies for sinonasal and nasopharyngeal malignancies. It analyzes the role of adjuvant radiotherapy, the potential of intensity-modulated proton therapy (IMPT), and the relevance of de-escalation strategies nasopharyngeal carcinoma (NPC). Additionally, it discusses hyperfractionation in re-irradiation in NPC. RECENT FINDINGS: Adjuvant radiotherapy remains pivotal for sinonasal tumors, improving locoregional control and survival, notably in squamous cell carcinomas, adenocarcinomas, and adenoid cystic carcinomas. IMPT promises enhanced outcomes by sparing healthy tissues, potentially improving patients' quality of life. For select stage II/T3N0 NPC, radiotherapy alone offers comparable outcomes to concurrent chemoradiotherapy, with fewer adverse events and improved quality of life. Selective neck irradiation in NPC patients with uninvolved necks maintains oncologic outcomes while reducing late toxicity. Hyperfractionation in re-irradiation shows promise in lowering late toxicities and improving overall survival, particularly in undifferentiated sinonasal carcinomas. SUMMARY: This review underscores the significance of adjuvant radiotherapy and the potential of advanced radiation techniques in optimizing sinonasal and nasopharyngeal malignancy outcomes. It emphasizes evolving de-escalation methods and individualized, evidence-based approaches. Future research will further refine strategies for these challenging malignancies. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | squamous cell carcinoma; carcinoma, squamous cell; quality of life; radiation oncology; nasopharynx carcinoma; nasopharyngeal carcinoma; nasopharynx tumor; nasopharyngeal neoplasms; humans; human |
| Journal Title: | Current Opinion in Otolaryngology & Head and Neck Surgery |
| Volume: | 32 |
| Issue: | 1 |
| ISSN: | 1068-9508 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2024-02-01 |
| Start Page: | 5 |
| End Page: | 13 |
| Language: | English |
| DOI: | 10.1097/moo.0000000000000942 |
| PUBMED: | 38116957 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Nancy Y. Lee -- Source: Scopus |
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