Estimating the benefit of preoperative systemic therapy to reduce the extent of breast cancer surgery: Current standard and future directions Journal Article
| Author: | Montagna, G. |
| Editors: | Al Jarroudi, O.; El Bairi, K.; Curigliano, G. |
| Article Title: | Estimating the benefit of preoperative systemic therapy to reduce the extent of breast cancer surgery: Current standard and future directions |
| Abstract: | Once reserved for locally advanced tumors which were deemed inoperable at presentation, preoperative systemic therapy (PST) is nowadays increasingly used to treat early breast cancer. PST allows for in vivo assessment of tumor response, for tailoring of adjuvant systemic therapy and for de-escalation of breast and the axillary surgery. Increased rates of pathological complete response together with more accurate response assessment and surgical planning have led to a significant reduction in surgical morbidity. While surgical assessment remains the standard of care, ongoing studies are evaluating whether surgery can be omitted in patients who achieve a complete pathological response. In this chapter, I will review the impact of PST on surgical de-escalation and the data supporting the safety of this approach. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023. |
| Keywords: | surgical technique; cancer recurrence; multimodality cancer therapy; united states; combined modality therapy; cancer staging; follow up; diagnostic accuracy; sentinel lymph node biopsy; breast cancer; breast; mastectomy; epidermal growth factor receptor 2; odds ratio; practice guideline; in vivo study; breast neoplasms; prediction; false negative result; standardization; feasibility study; preoperative period; breast tumor; clinical research; multivariate analysis; clinical effectiveness; preoperative treatment; axilla; hormone receptor; breast surgery; axillary lymph node dissection; ipsilateral breast tumor recurrence; recurrence free survival; futurology; pathological complete response; pathologic complete response; diagnostic test accuracy study; breast-conserving surgery; breast cancer surgery; humans; human; female; preoperative systemic therapy; axillary surgery; therapy escalation; surgical de-escalation; axillary recurrence free survival |
| Journal Title: | Cancer Treatment and Research |
| Volume: | 188 |
| ISSN: | 0927-3042 |
| Publisher: | Springer |
| Date Published: | 2023-01-01 |
| Start Page: | 149 |
| End Page: | 174 |
| Language: | English |
| DOI: | 10.1007/978-3-031-33602-7_6 |
| PROVIDER: | scopus |
| PUBMED: | 38175345 |
| DOI/URL: | |
| Notes: | This book chapter is part of the book Cancer Treatment and Research: Innovative Concepts (978-3-031-33601-0) -- Source: Scopus |
