Abstract: |
This chapter provides answers to practice-based questions with case studies covering the new principles of diagnosis, classification, staging, treatment, and outcomes in the rapidly advancing field of metastatic esophagogastric cancer. The intent of treatment for metastatic esophagogastric cancer is to control the disease and provide palliation. The chapter discusses recent seminal changes in therapy for metastatic esophagogastric cancer, which involves the addition of immune checkpoint inhibitors to first-line therapy for any cancer of the esophagus, gastroesophageal junction, or stomach. It also discusses the standard-of-care for second-line therapy and focus on emerging targets in this virulent disease. The chapter also provides expert guidance in the areas of cancer-related uncertainties and controversies, including experience-based discussions. © 2024 John Wiley & Sons Ltd. |