E7820, an anti-cancer sulfonamide, degrades RBM39 in patients with splicing factor mutant myeloid malignancies: A phase II clinical trial Research Letter

   

Authors:	Bewersdorf, J. P.; Stahl, M.; Taylor, J.; Mi, X.; Chandhok, N. S.; Watts, J.; Derkach, A.; Wysocki, M.; Lu, S. X.; Bourcier, J.; Hogg, S. J.; Rahman, J.; Chaudhry, S.; Totiger, T. M.; Abdel-Wahab, O.; Stein, E. M.
Title:	E7820, an anti-cancer sulfonamide, degrades RBM39 in patients with splicing factor mutant myeloid malignancies: A phase II clinical trial
Keywords:	clinical article; controlled study; treatment response; aged; unclassified drug; chronic myelomonocytic leukemia; gene mutation; human cell; overall survival; genetics; clinical trial; neutropenia; cancer recurrence; cancer growth; diarrhea; drug efficacy; drug safety; patient selection; side effect; treatment duration; cancer patient; follow up; antineoplastic agent; neoplasm; neoplasms; protein blood level; gene; multiple cycle treatment; phase 2 clinical trial; gene expression; anemia; protein degradation; genetic variability; gene frequency; antineoplastic activity; in vitro study; drug effect; mutational analysis; cancer mortality; alanine aminotransferase blood level; aspartate aminotransferase blood level; coughing; alanine aminotransferase; aspartate aminotransferase; cancer regression; correlation analysis; myelodysplastic syndrome; drug mechanism; messenger rna; sulfonamide; sulfonamides; western blotting; patient coding; allogeneic hematopoietic stem cell transplantation; cell count; indoles; indole derivative; rna splicing; peripheral blood mononuclear cell; blast cell; clinical outcome; hypertransaminasemia; acute myeloid leukemia; overall response rate; Common Terminology Criteria for Adverse Events; very elderly; humans; human; male; female; article; sf3b1 gene; rna splicing factor; rna splicing factors; srsf2 gene; clinical trial protocol; mrna expression level; u2af1 gene; e 7820; splicing factor rbm39; n-(3-cyano-4-methyl-1h-indol-7-yl)-3-cyanobenzene-sulfonamide; dcaf15 gene; variant allele fraction; zrsr gene
Journal Title:	Leukemia
Volume:	37
Issue:	12
ISSN:	0887-6924
Publisher:	Nature Publishing Group
Date Published:	2023-12-01
Start Page:	2512
End Page:	2516
Language:	English
DOI:	10.1038/s41375-023-02050-4
PUBMED:	37814121
PROVIDER:	scopus
PMCID:	PMC10681888
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85173969050&doi=10.1038%2fs41375-023-02050-4&partnerID=40&md5=f1e63f07f6038d3cab34bd000e053ce9
Notes:	Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/212377