Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome Journal Article
| Authors: | Kolodziejczak, A. S.; Guerrini-Rousseau, L.; Planchon, J. M.; Ecker, J.; Selt, F.; Mynarek, M.; Obrecht, D.; Sill, M.; Autry, R. J.; Stutheit-Zhao, E.; Hirsch, S.; Amouyal, E.; Dufour, C.; Ayrault, O.; Torrejon, J.; Waszak, S. M.; Ramaswamy, V.; Pentikainen, V.; Demir, H. A.; Clifford, S. C.; Schwalbe, E. C.; Massimi, L.; Snuderl, M.; Galbraith, K.; Karajannis, M. A.; Hill, K.; Li, B. K.; Walsh, M.; White, C. L.; Redmond, S.; Loizos, L.; Jakob, M.; Kordes, U. R.; Schmid, I.; Hauer, J.; Blattmann, C.; Filippidou, M.; Piccolo, G.; Scheurlen, W.; Farrag, A.; Grund, K.; Sutter, C.; Pietsch, T.; Frank, S.; Schewe, D. M.; Malkin, D.; Ben-Arush, M.; Sehested, A.; Wong, T. T.; Wu, K. S.; Liu, Y. L.; Carceller, F.; Mueller, S.; Stoller, S.; Taylor, M. D.; Tabori, U.; Bouffet, E.; Kool, M.; Sahm, F.; von Deimling, A.; Korshunov, A.; von Hoff, K.; Kratz, C. P.; Sturm, D.; Jones, D. T. W.; Rutkowski, S.; van Tilburg, C. M.; Witt, O.; Bougeard, G.; Pajtler, K. W.; Pfister, S. M.; Bourdeaut, F.; Milde, T. |
| Article Title: | Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome |
| Abstract: | BACKGROUND: The prognosis for Li-Fraumeni syndrome (LFS) patients with medulloblastoma (MB) is poor. Comprehensive clinical data for this patient group is lacking, challenging the development of novel therapeutic strategies. Here, we present clinical and molecular data on a retrospective cohort of pediatric LFS MB patients. METHODS: In this multinational, multicenter retrospective cohort study, LFS patients under 21 years with MB and class 5 or class 4 constitutional TP53 variants were included. TP53 mutation status, methylation subgroup, treatment, progression free- (PFS) and overall survival (OS), recurrence patterns, and incidence of subsequent neoplasms were evaluated. RESULTS: The study evaluated 47 LFS individuals diagnosed with MB, mainly classified as DNA methylation subgroup "SHH_3" (86%). The majority (74%) of constitutional TP53 variants represented missense variants. The 2- and 5-year (y-) PFS were 36% and 20%, and 2- and 5y-OS were 53% and 23%, respectively. Patients who received postoperative radiotherapy (RT) (2y-PFS: 44%, 2y-OS: 60%) or chemotherapy before RT (2y-PFS: 32%, 2y-OS: 48%) had significantly better clinical outcome then patients who were not treated with RT (2y-PFS: 0%, 2y-OS: 25%). Patients treated according to protocols including high-intensity chemotherapy and patients who received only maintenance-type chemotherapy showed similar outcomes (2y-PFS: 42% and 35%, 2y-OS: 68% and 53%, respectively). CONCLUSIONS: LFS MB patients have a dismal prognosis. In the presented cohort use of RT significantly increased survival rates, whereas chemotherapy intensity did not influence their clinical outcome. Prospective collection of clinical data and development of novel treatments are required to improve the outcome of LFS MB patients. © The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
| Keywords: | survival; child; retrospective studies; genetics; clinical trial; prospective study; prospective studies; retrospective study; protein p53; multicenter study; medulloblastoma; tumor suppressor protein p53; li-fraumeni syndrome; cerebellar neoplasms; germ-line mutation; cerebellum tumor; complication; tp53; germline mutation; humans; human; li–fraumeni syndrome |
| Journal Title: | Neuro-Oncology |
| Volume: | 25 |
| Issue: | 12 |
| ISSN: | 1522-8517 |
| Publisher: | Oxford University Press |
| Date Published: | 2023-12-01 |
| Start Page: | 2273 |
| End Page: | 2286 |
| Language: | English |
| DOI: | 10.1093/neuonc/noad114 |
| PUBMED: | 37379234 |
| PROVIDER: | scopus |
| PMCID: | PMC10708940 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
141Karajannis -
156Walsh -
18Hill -
8
Li
Related MSK Work