| Abstract: |
In accordance with the World Health Organization’s latest classification published in 2020, soft tissue neoplasms are categorized based on their apparent tissue of origin or line of differentiation into adipocytic, fibroblastic/myofibroblastic, fibrohistiocytic, vascular, perivascular, smooth muscle, skeletal muscle, chondrogenic, or peripheral nerve sheath. Bone tumors are similarly categorized into chondrogenic, osteogenic, fibroblastic, vascular, osteoclastic giant cell-rich, notochordal, and hematopoietic. Neoplasms of uncertain line of differentiation and undifferentiated round cell sarcomas are also included. In this chapter, we summarize the clinical presentation, histopathologic findings, and most importantly, the molecular pathogenesis of selected soft tissue and bone tumors. © 2024 Elsevier Inc. All rights reserved. |
