NEN in a dish: A patient-derived organoid biobank illuminates potential novel therapeutic opportunities for neuroendocrine neoplasms Editorial
| Authors: | Gerstberger, S.; Ganesh, K. |
| Title: | NEN in a dish: A patient-derived organoid biobank illuminates potential novel therapeutic opportunities for neuroendocrine neoplasms |
| Abstract: | Neuroendocrine neoplasms are rare cancers with limited treatment options and preclinical models. In this issue of Cancer Cell, Dayton et al. establish a patient-derived tumor organoid biobank encompassing pulmonary low-grade neuroendocrine tumors (LNETs) and high-grade neuroendocrine carcinomas (LCNECs), identifying novel biomarker-dependent therapeutic vulnerabilities using niche perturbation and drug response assays. © 2023 Elsevier Inc. |
| Keywords: | genetics; histopathology; note; cancer grading; carboplatin; protein bcl 2; gene expression profiling; etoposide; lung neoplasms; epidermal growth factor receptor; pathology; transcriptomics; tumor marker; neuroendocrine tumor; lung tumor; neuroendocrine tumors; neuroendocrine carcinoma; carcinoma, neuroendocrine; small cell lung cancer; large cell neuroendocrine carcinoma; b raf kinase inhibitor; nicotinamide; navitoclax; mitogen activated protein kinase kinase inhibitor; transcription factor mash1; alisertib; humans; human; neurogenic differentiation factor; organoid; biobank; biological specimen banks |
| Journal Title: | Cancer Cell |
| Volume: | 41 |
| Issue: | 12 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2023-12-11 |
| Start Page: | 2014 |
| End Page: | 2016 |
| Language: | English |
| DOI: | 10.1016/j.ccell.2023.11.006 |
| PUBMED: | 38086333 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Note -- Source: Scopus |
