CDKN2A/B mutations and allele-specific alterations stratify survival outcomes in IDH-mutant astrocytomas Research Letter


Authors: Hickman, R. A.; Gedvilaite, E.; Ptashkin, R.; Reiner, A. S.; Cimera, R.; Nandakumar, S.; Price, A.; Vanderbilt, C.; Fahy, T.; Young, R. J.; Miller, A. M.; Mellinghoff, I. K.; Rosenblum, M. K.; Ladanyi, M.; Arcila, M. E.; Zhang, Y.; Brannon, A. R.; Bale, T. A.
Title: CDKN2A/B mutations and allele-specific alterations stratify survival outcomes in IDH-mutant astrocytomas
Keywords: gene mutation; major clinical study; overall survival; gene deletion; genetics; mutation; note; brain tumor; glioma; brain neoplasms; allele; cohort analysis; alleles; heterozygosity loss; cyclin dependent kinase inhibitor 2a; cyclin-dependent kinase inhibitor p16; astrocytoma; isocitrate dehydrogenase; copy number variation; cyclin dependent kinase inhibitor 2b; humans; human; tumor mutational burden; cdkn2a protein, human; idh mutant astrocytoma
Journal Title: Acta Neuropathologica
Volume: 146
Issue: 6
ISSN: 0001-6322
Publisher: Springer  
Date Published: 2023-12-01
Start Page: 845
End Page: 847
Language: English
DOI: 10.1007/s00401-023-02639-0
PUBMED: 37831210
PROVIDER: scopus
PMCID: PMC10628020
DOI/URL:
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Tejus A. Bale -- Source: Scopus
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MSK Authors
  1. Anne S Reiner
    248 Reiner
  2. Robert J Young
    228 Young
  3. Marc Rosenblum
    424 Rosenblum
  4. Marc Ladanyi
    1326 Ladanyi
  5. Maria Eugenia Arcila
    657 Arcila
  6. Angela Rose Brannon
    99 Brannon
  7. Alexandra Miller
    74 Miller
  8. Robert Sime Cimera
    28 Cimera
  9. Yanming Zhang
    199 Zhang
  10. Tejus Bale
    122 Bale
  11. Richard Andrew Hickman
    22 Hickman
  12. Adam Ryan Price
    6 Price
  13. Tara Annmarie Fahy
    4 Fahy