Vepafestinib: a RET-selective inhibitor with enhanced CNS penetrance targets therapy-resistant mutants Editorial
| Authors: | Odintsov, I.; Somwar, R. |
| Title: | Vepafestinib: a RET-selective inhibitor with enhanced CNS penetrance targets therapy-resistant mutants |
| Abstract: | We sought to develop a pharmacologically advanced inhibitor of the oncoprotein RET. Vepafestinib potently inhibited on-target mutants that confer resistance to approved RET inhibitors while exerting superior efficacy against intracranial disease due to enhanced penetration and retention in the brain. |
| Journal Title: | Nature Cancer |
| Volume: | 4 |
| Issue: | 9 |
| ISSN: | 2662-1347 |
| Publisher: | Nature Research |
| Date Published: | 2023-09-01 |
| Start Page: | 1220 |
| End Page: | 1221 |
| Language: | English |
| ACCESSION: | WOS:001071303600004 |
| DOI: | 10.1038/s43018-023-00631-x |
| PROVIDER: | wos |
| PUBMED: | 37743367 |
| Notes: | Source: Wos |
