Uniting dual-modal MRI/chemiluminescence nanotheranostics: Spatially and sensitively self-reporting photodynamic therapy in oral cancer Journal Article
| Authors: | Tao, Y.; Yan, C.; Wu, Y.; Li, D.; Li, J.; Xie, Y.; Cheng, Y.; Xu, Y.; Yang, K.; Zhu, W. H.; Guo, Z. |
| Article Title: | Uniting dual-modal MRI/chemiluminescence nanotheranostics: Spatially and sensitively self-reporting photodynamic therapy in oral cancer |
| Abstract: | Unpredictable in vivo therapeutic feedback of reactive oxygen species (ROS) efficiency is the major bottleneck of photodynamic therapy (PDT). Herein, novel PDT-based nanotheranostics Pa–Mn&CH-A@P are elaborately constructed for in vivo tracking biodistribution and in situ self-reporting PDT, which innovatively unites magnetic resonance imaging (MRI) and chemiluminescence (CL) signals. Taking advantages of the versatility of lanthanide coordination chemistry and flash nanoprecipitation (FNP) technology, photosensitizers, MRI, and CL agents are unprecedently integrated within a stable and uniform nanotheranostic. Specifically, MRI signal offers detailed dose distribution of nanotheranostics with high-spatial resolution, and CL signal timely performs in situ evaluation of ROS generation with high sensitivity. This dual-modal MRI/CL nanotheranostic makes a breakthrough in high fidelity feedback for oral tumor, conquering the inherent unpredictable obstacles on spatially and sensitively reporting PDT. © 2023 Wiley-VCH GmbH. |
| Keywords: | magnetic resonance imaging; fluorescence; reactive oxygen species; in-vivo; photodynamic therapy; fluorescence imaging; oral cancer; coordination reactions; biodistributions; chemiluminescence; photosensitizers; co-ordination chemistries; nanotheranostics; chemiluminescence probes; flash nanoprecipitation; chemiluminescence probe; nano precipitations; self-reporting |
| Journal Title: | Advanced Functional Materials |
| Volume: | 33 |
| Issue: | 40 |
| ISSN: | 1616-301X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2023-10-02 |
| Start Page: | 2303240 |
| Language: | English |
| DOI: | 10.1002/adfm.202303240 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
