Imaging the side effects of CAR T cell therapy: A primer for the practicing radiologist Review
| Authors: | Huang, S.; de Jong, D.; Das, J. P.; Widemon, R. S.; Braumuller, B.; Paily, J.; Deng, A.; Liou, C.; Roa, T.; Huang, A.; Ma, H.; D'Souza, B.; Leb, J.; L'Hereaux, J.; Nguyen, P.; Luk, L.; Francescone, M.; Yeh, R.; Maccarrone, V.; Dercle, L.; Salvatore, M. M.; Capaccione, K. M. |
| Review Title: | Imaging the side effects of CAR T cell therapy: A primer for the practicing radiologist |
| Abstract: | Chimeric antigen receptor (CAR) T cell therapy is a revolutionary form of immunotherapy that has proven to be efficacious in the treatment of many hematologic cancers. CARs are modified T lymphocytes that express an artificial receptor specific to a tumor-associated antigen. These engineered cells are then reintroduced to upregulate the host immune responses and eradicate malignant cells. While the use of CAR T cell therapy is rapidly expanding, little is known about how common side effects such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS) present radiographically. Here we provide a comprehensive review of how side effects present in different organ systems and how they can be optimally imaged. Early and accurate recognition of the radiographic presentation of these side effects is critical to the practicing radiologist and their patients so that these side effects can be promptly identified and treated. © 2023 The Association of University Radiologists |
| Keywords: | adult; human cell; review; neurotoxicity; nuclear magnetic resonance imaging; computer assisted tomography; ultrasound; pneumonia; acute kidney failure; immunology; radiologist; heart failure; brain disease; chimeric antigen receptor; imaging; effector cell; pleura effusion; thorax radiography; encephalitis; abdominal radiography; cardiomyopathy; hepatosplenomegaly; adverse event; gastritis; adverse events; cytokine release syndrome; pelvis radiography; cardiovascular magnetic resonance; human; chimeric antigen receptor t-cell immunotherapy; car t cell therapy; immune effector cell associated neurotoxicity; organ systems |
| Journal Title: | Academic Radiology |
| Volume: | 30 |
| Issue: | 11 |
| ISSN: | 1076-6332 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2023-11-01 |
| Start Page: | 2712 |
| End Page: | 2727 |
| Language: | English |
| DOI: | 10.1016/j.acra.2023.04.004 |
| PUBMED: | 37394411 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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