Review of outcomes after salvage surgery for recurrent squamous cell carcinoma of the head and neck Review
| Authors: | Hartl, D. M.; Guerlain, J.; Gorphe, P.; Kapre, M.; Kapre Gupta, N.; Saba, N. F.; Robbins, K. T.; Ronen, O.; Rodrigo, J. P.; Strojan, P.; Mäkitie, A. A.; Kowalski, L. P.; Shah, J. P.; Ferlito, A. |
| Review Title: | Review of outcomes after salvage surgery for recurrent squamous cell carcinoma of the head and neck |
| Abstract: | Surgery with adjuvant chemoradiotherapy or chemoradiotherapy is the mainstay in treatment for advanced stage head and neck squamous cell carcinoma; however, locoregional recurrences are frequent. Salvage surgery could be proposed in selected patients to improve local control, disease-free, and overall survival. Factors for improved disease-free and overall survival in patients treated with salvage surgery include age, tumor location, the initial T stage, HPV status, resection margins, and the time elapsing from the initial treatment. Clinical trials with adjuvant therapies have shown promise after salvage surgery in terms of tolerance and response, but clinical guidelines for using these adjuvant treatments are currently lacking. The aim of this review is to present current knowledge concerning the incidence and management of recurrent head and neck squamous cell carcinoma and current data concerning survival and morbidity after salvage surgery. © 2023 by the authors. |
| Keywords: | cancer survival; cancer surgery; overall survival; review; cancer recurrence; laryngectomy; neck dissection; salvage therapy; disease free survival; cancer staging; follow up; morbidity; head and neck cancer; tumor recurrence; recurrent disease; nasopharynx carcinoma; photodynamic therapy; chemoradiation; perineural invasion; oropharynx carcinoma; chemoradiotherapy; wart virus; hypopharynx; recurrence free survival; surgical margin; head and neck squamous cell carcinoma; larynx tumor; squamous cell; salvage surgery; re-irradiation; adjuvant chemoradiotherapy; human; local disease free survival |
| Journal Title: | Cancers |
| Volume: | 15 |
| Issue: | 19 |
| ISSN: | 2072-6694 |
| Publisher: | MDPI |
| Date Published: | 2023-10-01 |
| Start Page: | 4692 |
| Language: | English |
| DOI: | 10.3390/cancers15194692 |
| PROVIDER: | scopus |
| PMCID: | PMC10571840 |
| PUBMED: | 37835386 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
