Characteristics and prognostic impact of IDH mutations in AML: A COG, SWOG, and ECOG analysis Journal Article
| Authors: | Zarnegar-Lumley, S.; Alonzo, T. A.; Gerbing, R. B.; Othus, M.; Sun, Z.; Ries, R. E.; Wang, J.; Leonti, A.; Kutny, M. A.; Ostronoff, F.; Radich, J. P.; Appelbaum, F. R.; Pogosova-Agadjanyan, E. L.; O’Dwyer, K.; Tallman, M. S.; Litzow, M.; Atallah, E.; Cooper, T. M.; Aplenc, R. A.; Abdel-Wahab, O.; Gamis, A. S.; Luger, S.; Erba, H.; Levine, R.; Kolb, E. A.; Stirewalt, D. L.; Meshinchi, S.; Tarlock, K. |
| Article Title: | Characteristics and prognostic impact of IDH mutations in AML: A COG, SWOG, and ECOG analysis |
| Abstract: | Somatic mutations in isocitrate dehydrogenase (IDH) genes occur frequently in adult acute myeloid leukemia (AML) and less commonly in pediatric AML. The objective of this study was to describe the prevalence, mutational profile, and prognostic significance of IDH mutations in AML across age. Our cohort included 3141 patients aged between <1 month and 88 years treated on Children’s Cancer Group/Children’s Oncology Group (n = 1872), Southwest Oncology Group (n = 359), Eastern Cooperative Oncology Group (n = 397) trials, and in Beat AML (n = 333) and The Cancer Genome Atlas (n = 180) genomic characterization cohorts. We retrospectively analyzed patients in 4 age groups (age range, n): pediatric (0-17, 1744), adolescent/young adult (18-39, 444), intermediate-age (40-59, 640), older (≥60, 309). IDH mutations (IDHmut) were identified in 9.2% of the total cohort (n = 288; IDH1 [n = 123, 42.7%]; IDH2 [n = 165, 57.3%]) and were strongly correlated with increased age: 3.4% pediatric vs 21% older, P < .001. Outcomes were similar in IDHmut and IDH-wildtype (IDHWT) AML (event-free survival [EFS]: 35.6% vs 40.0%, P = .368; overall survival [OS]: 50.3% vs 55.4%, P = .196). IDH mutations frequently occurred with NPM1 (47.2%), DNMT3A (29.3%), and FLT3-internal tandem duplication (ITD) (22.4%) © 2023 American Society of Hematology. All rights reserved. |
| Journal Title: | Blood Advances |
| Volume: | 7 |
| Issue: | 19 |
| ISSN: | 2473-9529 |
| Publisher: | American Society of Hematology |
| Date Published: | 2023-10-10 |
| Start Page: | 5941 |
| End Page: | 5953 |
| Language: | English |
| DOI: | 10.1182/bloodadvances.2022008282 |
| PUBMED: | 37267439 |
| PROVIDER: | scopus |
| PMCID: | PMC10562769 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
649Tallman -
775Levine -
573Abdel-Wahab
Related MSK Work