Entanglement of MAPK pathways with gene expression and its omnipresence in the etiology for cancer and neurodegenerative disorders Review
| Authors: | Chakraborty, J.; Chakraborty, S.; Chakraborty, S.; Narayan, M. N. |
| Review Title: | Entanglement of MAPK pathways with gene expression and its omnipresence in the etiology for cancer and neurodegenerative disorders |
| Abstract: | Mitogen Activated Protein Kinase (MAPK) is one of the most well characterized cellular signaling pathways that controls fundamental cellular processes including proliferation, differentiation, and apoptosis. These cellular functions are consequences of transcription of regulatory genes that are influenced and regulated by the MAP-Kinase signaling cascade. MAP kinase components such as Receptor Tyrosine Kinases (RTKs) sense external cues or ligands and transmit these signals via multiple protein complexes such as RAS–RAF, MEK, and ERKs and eventually modulate the transcription factors inside the nucleus to induce transcription and other regulatory functions. Aberrant activation, dysregulation of this signaling pathway, and genetic alterations in any of these components results in the developmental disorders, cancer, and neurodegenerative disorders. Over the years, the MAPK pathway has been a prime pharmacological target, to treat complex human disorders that are genetically linked such as cancer, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The current review re-visits the mechanism of MAPK pathways in gene expression regulation. Further, a current update on the progress of the mechanistic understanding of MAPK components is discussed from a disease perspective. © 2023 |
| Keywords: | mitogen activated protein kinase; protein phosphorylation; review; raf protein; cell proliferation; apoptosis; gene expression; stress activated protein kinase; epidermal growth factor receptor; regulatory mechanism; ras protein; parkinson disease; multiple sclerosis; alzheimer disease; degenerative disease; synaptophysin; map kinases; amyotrophic lateral sclerosis; p38; parkinson's disease; mapk signaling; cancer; human; malignant neoplasm; alzheimer's' disease; erk/jnk; cancer signaling |
| Journal Title: | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms |
| Volume: | 1866 |
| Issue: | 4 |
| ISSN: | 1874-9399 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2023-12-01 |
| Start Page: | 194988 |
| Language: | English |
| DOI: | 10.1016/j.bbagrm.2023.194988 |
| PUBMED: | 37739217 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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