Abstract: |
Sinonasal minor salivary gland tumors are rare occurrences and are more commonly malignant than benign. Adenoid cystic carcinomas represent, by far, the most frequently encountered tumors. Other salivary gland tumor histologic subtypes have scarcely been reported in the sinonasal tract. Gross examination can only provide a limited amount of information, seeing as most material is received in fragments. Histologically, salivary gland tumors can demonstrate significant morphologic overlap with one another, as well as with other non-salivary gland tumors in the differential diagnosis. In that regard, ancillary studies can be instrumental in identifying the key immunohistochemical and genomic features that are characteristic of each entity. The treatment of most tumors entails surgical resection with clear margins. Accurate identification of the high-risk categories (e.g., adenoid cystic carcinoma, salivary duct carcinoma) is essential to guide adjuvant treatment options such as radiotherapy, chemotherapy, and novel targeted therapy options. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023. |