A Rare case of primary cutaneous gamma-delta T-cell lymphoma with aberrant B-cell marker expression Journal Article

   


Authors: Trivedi, A.; Yabe, M.; Dogan, A.; Epstein-Peterson, Z. D.; Myskowski, P. L.; Arcila, M. E.; Linos, K.
Article Title: A Rare case of primary cutaneous gamma-delta T-cell lymphoma with aberrant B-cell marker expression
Abstract: ABSTRACT: Primary cutaneous gamma-delta T-cell lymphoma (PCGDTL) is a rare and diagnostically challenging primary skin lymphoma. We present a case of a 78-year-old otherwise healthy man who developed nonhealing nodules on his right posterior calf. Initial biopsy showed a dense, atypical, lymphoid infiltrate with gamma-delta and cytotoxic T-cell immunophenotypes. The diagnosis of PCGDTL was rendered; however, concurrent flow cytometry revealed expression of aberrant B-cell markers, including CD19 and cytoplasmic CD79a. Subsequent immunohistochemical studies corroborated this result. We report the extremely rare phenomenon of aberrant B-cell marker expression in PCGDTL, the first formally reported case to our knowledge. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Journal Title: American Journal of Dermatopathology
Volume: 45
Issue: 11
ISSN: 0193-1091
Publisher: Lippincott Williams & Wilkins  
Date Published: 2023-11-01
Start Page: 768
End Page: 772
Language: English
DOI: 10.1097/dad.0000000000002557
PUBMED: 37856740
PROVIDER: scopus
PMCID: PMC10593491
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174864495&doi=10.1097%2fDAD.0000000000002557&partnerID=40&md5=dc65cc8811f704283a5e680c3435a8ca
Notes: Article -- Source: Scopus
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MSK Authors
  1. Maria Eugenia Arcila
    657 Arcila
  2. Patricia Myskowski
    216 Myskowski
  3. Konstantinos Linos
    53 Linos
  4. Ahmet Dogan
    455 Dogan
  5. Mariko Yabe
    51 Yabe
  6. Zachary Drew Epstein-Peterson
    79 Epstein-Peterson
  7. Apoorva Trivedi
    2 Trivedi
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