Advances and challenges in conducting clinical trials with proton beam therapy Review
| Authors: | Choi, J. I.; Simone, C. B. 2nd; Lozano, A.; Frank, S. J. |
| Review Title: | Advances and challenges in conducting clinical trials with proton beam therapy |
| Abstract: | Advances in proton therapy have garnered much attention and speculation in recent years as the indications for proton therapy have grown beyond pediatric, prostate, spine, and ocular tumors. To achieve and maintain consistent access to this cancer treatment and to ensure the future viability and availability of proton centers in the United States, a call for evidence has been heard and answered by proton radiation oncologists. Answers provided in this review include the evolution of proton therapy research, rationale for proton clinical trial design, challenges in and barriers to the conduct of proton therapy research, and other unique considerations for the study of proton therapy. © 2023 Elsevier Inc. |
| Keywords: | child; survival rate; review; intensity modulated radiation therapy; clinical trials as topic; united states; cancer radiotherapy; radiation dose; pelvis; prospective study; quality of life; evidence based practice; cancer research; cancer therapy; health care utilization; prostate; protons; cancer control; proton radiation; health care access; radiation oncologists; proton; non small cell lung cancer; randomized controlled trial (topic); clinical trial (topic); proton therapy; humans; human; male; radiation oncologist |
| Journal Title: | Seminars in Radiation Oncology |
| Volume: | 33 |
| Issue: | 4 |
| ISSN: | 1053-4296 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2023-10-01 |
| Start Page: | 407 |
| End Page: | 415 |
| Language: | English |
| DOI: | 10.1016/j.semradonc.2023.06.006 |
| PUBMED: | 37684070 |
| PROVIDER: | scopus |
| PMCID: | PMC10503212 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding MSK author is J. Isabelle Choi -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work