Pathogenesis of cancers derived from thyroid follicular cells Review

  


Authors: Fagin, J. A.; Krishnamoorthy, G. P.; Landa, I.
Review Title: Pathogenesis of cancers derived from thyroid follicular cells
Abstract: The genomic simplicity of differentiated cancers derived from thyroid follicular cells offers unique insights into how oncogenic drivers impact tumour phenotype. Essentially, the main oncoproteins in thyroid cancer activate nodes in the receptor tyrosine kinase–RAS–BRAF pathway, which constitutively induces MAPK signalling to varying degrees consistent with their specific biochemical mechanisms of action. The magnitude of the flux through the MAPK signalling pathway determines key elements of thyroid cancer biology, including differentiation state, invasive properties and the cellular composition of the tumour microenvironment. Progression of disease results from genomic lesions that drive immortalization, disrupt chromatin accessibility and cause cell cycle checkpoint dysfunction, in conjunction with a tumour microenvironment characterized by progressive immunosuppression. This Review charts the genomic trajectories of these common endocrine tumours, while connecting them to the biological states that they confer. © 2023, Springer Nature Limited.
Keywords: signal transduction; oncoprotein; genetics; metabolism; pathology; protein tyrosine kinase; oncogene proteins; thyroid neoplasms; receptor protein-tyrosine kinases; b raf kinase; thyroid tumor; proto-oncogene proteins b-raf; tumor microenvironment; humans; human; thyroid follicular cell; thyroid epithelial cells
Journal Title: Nature Reviews Cancer
Volume: 23
Issue: 9
ISSN: 1474-175X
Publisher: Nature Publishing Group  
Date Published: 2023-09-01
Start Page: 631
End Page: 650
Language: English
DOI: 10.1038/s41568-023-00598-y
PUBMED: 37438605
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164816137&doi=10.1038%2fs41568-023-00598-y&partnerID=40&md5=cadc6a9cf6f42b8783b3f2c42ed7d9e3
Notes: Source: Scopus
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MSK Authors
  1. James A Fagin
    180 Fagin
  2. Inigo Landa-Lopez
    19 Landa-Lopez
  3. Gnana Prakasam Krishnamoorthy
    18 Krishnamoorthy
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