Spatial analyses of immune cell infiltration in cancer: Current methods and future directions: A report of the International Immuno-Oncology Biomarker Working Group on breast cancer Review

  

Authors:	Page, D. B.; Broeckx, G.; Jahangir, C. A.; Verbandt, S.; Gupta, R. R.; Thagaard, J.; Khiroya, R.; Kos, Z.; Abduljabbar, K.; Acosta Haab, G.; Acs, B.; Akturk, G.; Almeida, J. S.; Alvarado-Cabrero, I.; Azmoudeh-Ardalan, F.; Badve, S.; Baharun, N. B.; Bellolio, E. R.; Bheemaraju, V.; Blenman, K. R. M.; Botinelly Mendonça Fujimoto, L.; Bouchmaa, N.; Burgues, O.; Cheang, M. C. U.; Ciompi, F.; Cooper, L. A. D.; Coosemans, A.; Corredor, G.; Dantas Portela, F. L.; Deman, F.; Demaria, S.; Dudgeon, S. N.; Elghazawy, M.; Ely, S.; Fernandez-Martín, C.; Fineberg, S.; Fox, S. B.; Gallagher, W. M.; Giltnane, J. M.; Gnjatic, S.; Gonzalez-Ericsson, P. I.; Grigoriadis, A.; Halama, N.; Hanna, M. G.; Harbhajanka, A.; Hardas, A.; Hart, S. N.; Hartman, J.; Hewitt, S.; Hida, A. I.; Horlings, H. M.; Husain, Z.; Hytopoulos, E.; Irshad, S.; Janssen, E. A. M.; Kahila, M.; Kataoka, T. R.; Kawaguchi, K.; Kharidehal, D.; Khramtsov, A. I.; Kiraz, U.; Kirtani, P.; Kodach, L. L.; Korski, K.; Kovács, A.; Laenkholm, A. V.; Lang-Schwarz, C.; Larsimont, D.; Lennerz, J. K.; Lerousseau, M.; Li, X.; Ly, A.; Madabhushi, A.; Maley, S. K.; Manur Narasimhamurthy, V.; Marks, D. K.; McDonald, E. S.; Mehrotra, R.; Michiels, S.; Minhas, F. U. A. A.; Mittal, S.; Moore, D. A.; Mushtaq, S.; Nighat, H.; Papathomas, T.; Penault-Llorca, F.; Perera, R. D.; Pinard, C. J.; Pinto-Cardenas, J. C.; Pruneri, G.; Pusztai, L.; Rahman, A.; Rajpoot, N. M.; Rapoport, B. L.; Rau, T. T.; Reis-Filho, J. S.; Ribeiro, J. M.; Rimm, D.; Vincent-Salomon, A.; Salto-Tellez, M.; Saltz, J.; Sayed, S.; Siziopikou, K. P.; Sotiriou, C.; Stenzinger, A.; Sughayer, M. A.; Sur, D.; Symmans, F.; Tanaka, S.; Taxter, T.; Tejpar, S.; Teuwen, J.; Thompson, E. A.; Tramm, T.; Tran, W. T.; van der Laak, J.; van Diest, P. J.; Verghese, G. E.; Viale, G.; Vieth, M.; Wahab, N.; Walter, T.; Waumans, Y.; Wen, H. Y.; Yang, W.; Yuan, Y.; Adams, S.; Bartlett, J. M. S.; Loibl, S.; Denkert, C.; Savas, P.; Loi, S.; Salgado, R.; Specht Stovgaard, E.
Review Title:	Spatial analyses of immune cell infiltration in cancer: Current methods and future directions: A report of the International Immuno-Oncology Biomarker Working Group on breast cancer
Abstract:	Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized method for describing or analyzing spatial immune cell data, and most reported spatial analyses are rudimentary. In this review, we provide an overview of two approaches for reporting and analyzing spatial data (raster versus vector-based). We then provide a compendium of spatial immune cell metrics that have been reported in the literature, summarizing prognostic associations in the context of a variety of cancers. We conclude by discussing two well-described clinical biomarkers, the breast cancer stromal tumor infiltrating lymphocytes score and the colon cancer Immunoscore, and describe investigative opportunities to improve clinical utility of these spatial biomarkers. © 2023 The Pathological Society of Great Britain and Ireland. © 2023 The Pathological Society of Great Britain and Ireland.
Keywords:	tumor associated leukocyte; lymphocytes, tumor-infiltrating; biomarkers; biological marker; colonic neoplasms; colon tumor; benchmarking; tumor microenvironment; spatial statistics; spatial analysis; tumor infiltrating lymphocytes; spatial heterogeneity; immunoscore; humans; human; til; multispectral immunofluorescence; stil score
Journal Title:	Journal of Pathology
Volume:	260
Issue:	5
ISSN:	0022-3417
Publisher:	Wiley Blackwell
Date Published:	2023-08-01
Start Page:	514
End Page:	532
Language:	English
DOI:	10.1002/path.6165
PUBMED:	37608771
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85167992595&doi=10.1002%2fpath.6165&partnerID=40&md5=ee8365854461039d2d038fcb8bb35170
Notes:	Review -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/210038