The future of lymphedema: Potential therapeutic targets for treatment Review
| Authors: | Brown, S.; Campbell, A. C.; Kuonqui, K.; Sarker, A.; Park, H. J.; Shin, J.; Kataru, R. P.; Coriddi, M.; Dayan, J. H.; Mehrara, B. J. |
| Review Title: | The future of lymphedema: Potential therapeutic targets for treatment |
| Abstract: | Purpose of Review: This review aims to summarize the current knowledge regarding the pharmacological interventions studied in both experimental and clinical trials for secondary lymphedema. Recent Findings: Lymphedema is a progressive disease that results in tissue swelling, pain, and functional disability. The most common cause of secondary lymphedema in developed countries is an iatrogenic injury to the lymphatic system during cancer treatment. Despite its high incidence and severe sequelae, lymphedema is usually treated with palliative options such as compression and physical therapy. However, recent studies on the pathophysiology of lymphedema have explored pharmacological treatments in preclinical and early phase clinical trials. Summary: Many potential treatment options for lymphedema have been explored throughout the past two decades including systemic agents and topical approaches to decrease the potential toxicity of systemic treatment. Treatment strategies including lymphangiogenic factors, anti-inflammatory agents, and anti-fibrotic therapies may be used independently or in conjunction with surgical approaches. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
| Keywords: | lymphedema; vascular endothelial growth factor c; doxycycline; tacrolimus; captopril; pirfenidone; th2 cells; vegf-c; tetracyclines; non-steroidal anti-inflammatory drugs; nsaid; ace inhibitors; cd4 +; tgfb |
| Journal Title: | Current Breast Cancer Reports |
| Volume: | 15 |
| Issue: | 3 |
| ISSN: | 1943-4588 |
| Publisher: | Springer |
| Date Published: | 2023-09-01 |
| Start Page: | 233 |
| End Page: | 241 |
| Language: | English |
| DOI: | 10.1007/s12609-023-00491-5 |
| PROVIDER: | scopus |
| PMCID: | PMC10233555 |
| PUBMED: | 37359311 |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Babak Mehrara -- Source: Scopus |
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