Summary of research: Adjuvant nivolumab plus ipilimumab versus placebo for localized renal cell carcinoma after nephrectomy (CheckMate 914): A double-blind, randomized, phase 3 trial Journal Article
| Authors: | Motzer, R. J.; Russo, P.; Grünwald, V.; Tomita, Y.; Zurawski, B.; Parikh, O.; Buti, S.; Barthélémy, P.; Goh, J. C.; Ye, D.; Lingua, A.; Lattouf, J. B.; Albigès, L.; George, S.; Shuch, B.; Sosman, J.; Staehler, M.; Vázquez Estévez, S.; Simsek, B.; Spiridigliozzi, J.; Chudnovsky, A.; Bex, A. |
| Article Title: | Summary of research: Adjuvant nivolumab plus ipilimumab versus placebo for localized renal cell carcinoma after nephrectomy (CheckMate 914): A double-blind, randomized, phase 3 trial |
| Abstract: | This is a summary of a research article reporting Part A of the CheckMate 914 study (NCT03138512; EudraCT 2016-004502-34). Following surgery to remove renal cell carcinoma (RCC), people with a high risk of the cancer returning received nivolumab plus ipilimumab (adjuvant therapy) or placebo to see if this risk was reduced. The results of this study showed that the risk of RCC returning or death was not changed with adjuvant nivolumab plus ipilimumab treatment compared with placebo. In addition, people treated with nivolumab plus ipilimumab had more side effects compared with people treated with placebo (89% versus 57%). © 2023, The Author(s). |
| Journal Title: | Targeted Oncology |
| Volume: | 18 |
| Issue: | 5 |
| ISSN: | 1776-2596 |
| Publisher: | Springer |
| Date Published: | 2023-09-01 |
| Start Page: | 639 |
| End Page: | 641 |
| Language: | English |
| DOI: | 10.1007/s11523-023-00987-1 |
| PUBMED: | 37659025 |
| PROVIDER: | scopus |
| PMCID: | PMC10517884 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding MSK author is Robert J. Motzer -- Source: Scopus |
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