Spotlight on GOT2 in cancer metabolism Review
| Authors: | Kerk, S. A.; Garcia-Bermudez, J.; Birsoy, K.; Sherman, M. H.; Shah, Y. M.; Lyssiotis, C. A. |
| Review Title: | Spotlight on GOT2 in cancer metabolism |
| Abstract: | GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and dysregulated cancer metabolism. Despite this, recent work has emphasized the remarkable plasticity of cancer cells to employ compensatory pathways when GOT2 is inhibited. Here, we review the metabolic roles of GOT2, highlighting findings in both normal and cancer cells. We emphasize how cancer cells repurpose cell intrinsic metabolism and their flexibility when GOT2 is inhibited. We close by using this framework to discuss key considerations for future investigations into cancer metabolism. © 2023 Kerk et al. |
| Keywords: | review; nonhuman; pancreas cancer; protein function; cancer cell; pancreatic cancer; mitochondria; cell metabolism; mitochondrion; aspartic acid; nucleotide; tumor microenvironment; nucleotides; tumor metabolism; nucleotide metabolism; redox; human; oxidation reduction potential; aspartate aminotransferase isoenzyme 2; malignant neoplasm; transaminase |
| Journal Title: | OncoTargets and Therapy |
| Volume: | 16 |
| ISSN: | 1178-6930 |
| Publisher: | Dove Medical Press Ltd |
| Date Published: | 2023-08-22 |
| Start Page: | 695 |
| End Page: | 702 |
| Language: | English |
| DOI: | 10.2147/ott.S382161 |
| PROVIDER: | scopus |
| PMCID: | PMC10460182 |
| PUBMED: | 37635751 |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF and PubMed (in copied section) -- Source: Scopus |
