Immunophenotypic correlates of sustained MRD negativity in patients with multiple myeloma Journal Article
| Authors: | Coffey, D. G.; Maura, F.; Gonzalez-Kozlova, E.; Diaz-Mejia, J. J.; Luo, P.; Zhang, Y.; Xu, Y.; Warren, E. H.; Dawson, T.; Lee, B.; Xie, H.; Smith, E.; Ciardiello, A.; Cho, H. J.; Rahman, A.; Kim-Schulze, S.; Diamond, B.; Lesokhin, A.; Kazandjian, D.; Pugh, T. J.; Green, D. J.; Gnjatic, S.; Landgren, O. |
| Article Title: | Immunophenotypic correlates of sustained MRD negativity in patients with multiple myeloma |
| Abstract: | The role of the immune microenvironment in maintaining disease remission in patients with multiple myeloma (MM) is not well understood. In this study, we comprehensively profile the immune system in patients with newly diagnosed MM receiving continuous lenalidomide maintenance therapy with the aim of discovering correlates of long-term treatment response. Leveraging single-cell RNA sequencing and T cell receptor β sequencing of the peripheral blood and CyTOF mass cytometry of the bone marrow, we longitudinally characterize the immune landscape in 23 patients before and one year after lenalidomide exposure. We compare patients achieving sustained minimal residual disease (MRD) negativity to patients who never achieved or were unable to maintain MRD negativity. We observe that the composition of the immune microenvironment in both the blood and the marrow varied substantially according to both MRD negative status and history of autologous stem cell transplant, supporting the hypothesis that the immune microenvironment influences the depth and duration of treatment response. © 2023, Springer Nature Limited. |
| Keywords: | clinical article; controlled study; human tissue; treatment response; aged; human cell; lenalidomide; treatment duration; cancer patient; flow cytometry; phenotype; progression free survival; immune system; bortezomib; multiple myeloma; bone marrow; maintenance therapy; rna; t lymphocyte receptor beta chain; blood; regulatory t lymphocyte; patients; minimal residual disease; bone; long term care; immunophenotyping; lymphocyte antigen receptor; peripheral blood mononuclear cell; receptors, antigen, t-cell, alpha-beta; helper cell; carfilzomib; patient; tumor microenvironment; cell component; humans; human; male; female; article; mass cytometry; single cell rna seq |
| Journal Title: | Nature Communications |
| Volume: | 14 |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2023-09-02 |
| Start Page: | 5335 |
| Language: | English |
| DOI: | 10.1038/s41467-023-40966-8 |
| PUBMED: | 37660077 |
| PROVIDER: | scopus |
| PMCID: | PMC10475030 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- Source: Scopus |
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