Optimizing lung cancer radiotherapy treatments using personalized dose-response curves Journal Article

  


Authors: Deasy, J. O.; Jeong, J.; Thor, M.; Apte, A.; Jackson, A.; Chen, I.; Wu, A.; Rimner, A.
Article Title: Optimizing lung cancer radiotherapy treatments using personalized dose-response curves
Abstract: In this chapter we review the use of prediction models to personalize the physical parameters associated with lung cancer radiotherapy treatment planning, including the fractionation schedule. New models and data are continuing to emerge that support moving away from a one-size-fits-all, or one-size-fits-many approach. In most cases, radiotherapy for non-small lung cancer is a toxicity-limited treatment with still suboptimal tumor local control. We will discuss the dose-volume determinants, for important lung cancer radiotherapy endpoints, including esophagitis, pneumonitis, bronchial stenosis, and cardiotoxicity. We will discuss in detail tumor response and tumor local control modeling, and how to design a clinical trial to use personalized toxicity and tumor control curves to individualize dose and fractionation. The main point of this chapter is that a new clinical paradigm is emerging of using published and validated models to inform treatment decisions on a patient-specific basis. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
Keywords: overall survival; dose response; cancer radiotherapy; positron emission tomography; cell proliferation; tumor volume; esophagitis; lung cancer; radiation exposure; mathematical model; pneumonia; hypoxia; dosimetry; cardiotoxicity; fluorodeoxyglucose f 18; radiosensitivity; fractionation; radiation dose distribution; radiation pneumonia; decision support system; radiobiology; non small cell lung cancer; beam therapy; hypofractionated radiotherapy; human; personalized cancer therapy; oxygen enhancement ratio; bronchus stenosis
Journal Title: Medical Radiology
ISSN: 0942-5373
Publisher: Springer Nature  
Date Published: 2023-01-01
Start Page: 189
End Page: 212
Language: English
DOI: 10.1007/174_2022_307
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85171191501&doi=10.1007%2f174_2022_307&partnerID=40&md5=2aeeb2df9442f56ca613c686839e49b8
Notes: Book Chapter in "Advances in Radiation Oncology in Lung Cancer" (ISBN: 978-3-031-34846-4), which is part of a subseries of Medical Radiology called "Radiation Oncology" (ISSN: 2731-4715) -- Found in "Part III Basic Treatment Considerations" -- Source: Scopus
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MSK Authors
  1. Andreas Rimner
    524 Rimner
  2. Abraham Jing-Ching Wu
    400 Wu
  3. Andrew Jackson
    253 Jackson
  4. Joseph Owen Deasy
    524 Deasy
  5. Aditya Apte
    203 Apte
  6. Jeho Jeong
    37 Jeong
  7. Maria Elisabeth Thor
    148 Thor
  8. Ishita Chen
    16 Chen
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