γ-secretase fanning the fire of innate immunity Review
| Authors: | Liu, C.; Nikain, C.; Li, Y. M. |
| Review Title: | γ-secretase fanning the fire of innate immunity |
| Abstract: | Innate immunity is the first line of defense against pathogens, alerting the individual cell and surrounding area to respond to this potential invasion. γ-secretase is a transmembrane protease complex that plays an intricate role in nearly every stage of this innate immune response. Through regulation of pattern recognition receptors (PRR) such as TREM2 and RAGE γ-secretase can modulate pathogen recognition. γ-secretase can act on cytokine receptors such as IFNαR2 and CSF1R to dampen their signaling capacity. While γ-secretase-mediated regulated intramembrane proteolysis (RIP) can further moderate innate immune responses through downstream signaling pathways. Furthermore, γ-secretase has also been shown to be regulated by the innate immune system through cytokine signaling and γ-secretase modulatory proteins such as IFITM3 and Hif-1α. This review article gives an overview of how γ-secretase is implicated in innate immunity and the maintenance of its responses through potentially positive and negative feedback loops. © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. |
| Keywords: | signal transduction; metabolism; inflammation; innate immunity; immunity, innate; regulated intramembrane proteolysis; amyloid precursor protein secretases; secretase; cytokine signaling; ifitm3; hif1a |
| Journal Title: | Biochemical Society Transactions |
| Volume: | 51 |
| Issue: | 4 |
| ISSN: | 0300-5127 |
| Publisher: | Portland Press Ltd |
| Date Published: | 2023-08-01 |
| Start Page: | 1597 |
| End Page: | 1610 |
| Language: | English |
| DOI: | 10.1042/bst20221445 |
| PUBMED: | 37449907 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Yue-Ming Li -- Source: Scopus |
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