Peptide-assembled single-chain atomic crystal enhances pluripotent stem cell differentiation to neurons Journal Article
| Authors: | Kim, N. H.; Chae, S.; Yi, S. A.; Sa, D. H.; Oh, S.; Kang, E. S.; Kim, S.; Choi, K. H.; Lee, J.; Choi, J. Y.; Kim, Y. H. |
| Article Title: | Peptide-assembled single-chain atomic crystal enhances pluripotent stem cell differentiation to neurons |
| Abstract: | Nanomaterials hybridized with biological components have widespread applications. among many candidates, peptides are attractive in that their peptide sequences can self-assemble with the surface of target materials with high specificity without perturbing the intrinsic properties of nanomaterials. Here, a 1D hybrid nanomaterial was developed through self-assembly of a designed peptide. A hexagonal coiled-coil motif geometrically matched to the diameter of the inorganic nanomaterial was fabricated, whose hydrophobic surface was wrapped along the axis of the hydrophobic core of the coiled coil. Our morphological and spectroscopic analyses revealed rod-shaped, homogeneous peptide-inorganic nanomaterial complexes. Culturing embryonic stem cells on surfaces coated with this peptide-assembled single-chain atomic crystal increased the growth and adhesion of the embryonic stem cells. The hybridized nanomaterial also served as an ECM for brain organoids, accelerating the maturation of neurons. New methods to fabricate hybrid materials through peptide assembly can be applied. © 2023 American Chemical Society. |
| Keywords: | cytology; protein assembly; cell differentiation; neurons; peptide; chemistry; amino acid sequence; peptides; stem cells; embryonic stem cells; pluripotent stem cell; pluripotent stem cells; coiled coil; nerve cell; spectroscopic analysis; stem cell differentiation; surface chemistry; nanostructured materials; atoms; hybrid materials; hybrid material; single-chain atomic crystal; atomic crystals; hybrids material; inorganic nano materials; single chains |
| Journal Title: | Nano Letters |
| Volume: | 23 |
| Issue: | 15 |
| ISSN: | 1530-6984 |
| Publisher: | American Chemical Society |
| Date Published: | 2023-08-09 |
| Start Page: | 6859 |
| End Page: | 6867 |
| Language: | English |
| DOI: | 10.1021/acs.nanolett.3c00966 |
| PUBMED: | 37470721 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
