ISG15: A link between innate immune signaling, DNA replication, and genome stability Review
| Authors: | Wardlaw, C. P.; Petrini, J. H. J. |
| Review Title: | ISG15: A link between innate immune signaling, DNA replication, and genome stability |
| Abstract: | Interferon stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that is highly induced upon activation of interferon signaling and cytoplasmic DNA sensing pathways. As part of the innate immune system ISG15 acts to inhibit viral replication and particle release via the covalent conjugation to both viral and host proteins. Unlike ubiquitin, unconjugated ISG15 also functions as an intracellular and extra-cellular signaling molecule to modulate the immune response. Several recent studies have shown ISG15 to also function in a diverse array of cellular processes and pathways outside of the innate immune response. This review explores the role of ISG15 in maintaining genome stability, particularly during DNA replication, and how this relates to cancer biology. It puts forth the hypothesis that ISG15, along with DNA sensors, function within a DNA replication fork surveillance pathway to help maintain genome stability. © 2023 The Authors. BioEssays published by Wiley Periodicals LLC. |
| Keywords: | unclassified drug; genetics; review; interferon; ubiquitin; dna replication; protein function; metabolism; dna damage; cell function; transcription factor; cytokine; cytokines; dna; immune response; ubiquitination; genomic instability; innate immunity; immunity, innate; dna replication stress; cell cycle regulation; ubiquitins; genome stability; conjugation; covalent bond; interferons; physiological stress; cancer; isg15; interferon stimulated gene 15; extrachromosomal dna; immune signaling; malignant neoplasm; innate immune; isgylation; extracellular signaling; interferon signaling |
| Journal Title: | BioEssays |
| Volume: | 45 |
| Issue: | 7 |
| ISSN: | 0265-9247 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2023-07-01 |
| Start Page: | 2300042 |
| Language: | English |
| DOI: | 10.1002/bies.202300042 |
| PUBMED: | 37147792 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding authors are MSK authors: Christopher P. Wardlaw and John H.J. Petrini -- Source: Scopus |
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