Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gynecologic cancer Guidelines
| Authors: | Disis, M. L.; Adams, S. F.; Bajpai, J.; Butler, M. O.; Curiel, T.; Dodt, S. A.; Doherty, L.; Emens, L. A.; Friedman, C. F.; Gatti-Mays, M.; Geller, M. A.; Jazaeri, A.; John, V. S.; Kurnit, K. C.; Liao, J. B.; Mahdi, H.; Mills, A.; Zsiros, E.; Odunsi, K. |
| Title: | Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gynecologic cancer |
| Abstract: | Advanced gynecologic cancers have historically lacked effective treatment options. Recently, immune checkpoint inhibitors (ICIs) have been approved by the US Food and Drug Administration for the treatment of cervical cancer and endometrial cancer, offering durable responses for some patients. In addition, many immunotherapy strategies are under investigation for the treatment of earlier stages of disease or in other gynecologic cancers, such as ovarian cancer and rare gynecologic tumors. While the integration of ICIs into the standard of care has improved outcomes for patients, their use requires a nuanced understanding of biomarker testing, treatment selection, patient selection, response evaluation and surveillance, and patient quality of life considerations, among other topics. To address this need for guidance, the Society for Immunotherapy of Cancer (SITC) convened a multidisciplinary panel of experts to develop a clinical practice guideline. The Expert Panel drew on the published literature as well as their own clinical experience to develop evidence- and consensus-based recommendations to provide guidance to cancer care professionals treating patients with gynecologic cancer. © 2023 BioMed Central Ltd.. All rights reserved. |
| Keywords: | immunohistochemistry; treatment outcome; clinical trials as topic; outcome assessment; endometrium cancer; biological marker; cancer immunotherapy; consensus; melanoma; quality of life; ovary cancer; practice guideline; tumor biopsy; histology; sarcoma; genital neoplasms, female; immunotherapy; microsatellite instability; uterine cervix cancer; uterine cervical neoplasms; uterine cervix tumor; female genital tract tumor; guidelines as topic; programmed death 1 ligand 1; tumor microenvironment; vulva cancer; female genital tract cancer; immune checkpoint inhibitor; humans; human; female; article; pembrolizumab; liquid biopsy; tumor mutational burden; chloroplast dna; dostarlimab |
| Journal Title: | Journal for ImmunoTherapy of Cancer |
| Volume: | 11 |
| Issue: | 6 |
| ISSN: | 2051-1426 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2023-06-01 |
| Start Page: | e006624 |
| Language: | English |
| DOI: | 10.1136/jitc-2022-006624 |
| PUBMED: | 37295818 |
| PROVIDER: | scopus |
| PMCID: | PMC10277149 |
| DOI/URL: | |
| Notes: | Guidelines -- Erratum issued, see DOi: 10.1136/jitc-2022-006624corr1 -- Source: Scopus |
