Pevonedistat with azacitidine in older patients with TP53-mutated AML: A phase 2 study with laboratory correlates Research Letter
| Authors: | Saliba, A. N.; Kaufmann, S. H.; Stein, E. M.; Patel, P. A.; Baer, M. R.; Stock, W.; Deininger, M.; Blum, W.; Schiller, G. J.; Olin, R. L.; Litzow, M. R.; Lin, T. L.; Ball, B. J.; Boyiadzis, M. M.; Traer, E.; Odenike, O.; Arellano, M. L.; Walker, A.; Duong, V. H.; Kovacsovics, T.; Collins, R. H.; Shoben, A. B.; Heerema, N. A.; Foster, M. C.; Peterson, K. L.; Schneider, P. A.; Martycz, M.; Gana, T. J.; Rosenberg, L.; Marcus, S.; Yocum, A. O.; Chen, T.; Stefanos, M.; Mims, A. S.; Borate, U.; Burd, A.; Druker, B. J.; Levine, R. L.; Byrd, J. C.; Foran, J. M. |
| Title: | Pevonedistat with azacitidine in older patients with TP53-mutated AML: A phase 2 study with laboratory correlates |
| Keywords: | adult; cancer survival; controlled study; treatment response; aged; middle aged; gene mutation; overall survival; drug tolerability; neutropenia; cancer growth; follow up; letter; controlled clinical trial; multiple cycle treatment; phase 2 clinical trial; gene frequency; protein p53; pneumonia; cause of death; bone marrow biopsy; multicenter study; vein thrombosis; sepsis; pleura effusion; azacitidine; small intestine obstruction; cellulitis; leukemia remission; acute myeloid leukemia; tp53 gene; partial remission; human; variant allele frequency; pevonedistat; bone marrow aspiration; composite complete remission |
| Journal Title: | Blood Advances |
| Volume: | 7 |
| Issue: | 11 |
| ISSN: | 2473-9529 |
| Publisher: | American Society of Hematology |
| Date Published: | 2023-06-13 |
| Start Page: | 2360 |
| End Page: | 2363 |
| Language: | English |
| DOI: | 10.1182/bloodadvances.2022008625 |
| PUBMED: | 36315007 |
| PROVIDER: | scopus |
| PMCID: | PMC10230164 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Source: Scopus |
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