Spatiotemporal regulation of peripheral T cell tolerance Review
| Authors: | Brown, C. C.; Rudensky, A. Y. |
| Review Title: | Spatiotemporal regulation of peripheral T cell tolerance |
| Abstract: | The incomplete removal of T cells that are reactive against self-proteins during their differentiation in the thymus requires mechanisms of tolerance that prevent their effector function within the periphery. A further challenge is imposed by the need to establish tolerance to the holobiont self, which comprises a highly complex community of commensal microorganisms. Here, we review recent advances in the investigation of peripheral T cell tolerance, focusing on new insights into mechanisms of tolerance to the gut microbiota, including tolerogenic antigen-presenting cell types and immunomodulatory lymphocytes, and their layered ontogeny that underlies developmental windows for establishing intestinal tolerance. While emphasizing the intestine as a model tissue for studying peripheral T cell tolerance, we highlight overlapping and distinct pathways that underlie tolerance to self-antigens versus commensal antigens within a broader framework for immune tolerance. |
| Keywords: | dendritic cells; antigens; autoimmunity; immunity; differentiation; induction; inhibition; life; absence; metabolites |
| Journal Title: | Science |
| Volume: | 380 |
| Issue: | 6644 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2023-05-05 |
| Start Page: | 472 |
| End Page: | 478 |
| Language: | English |
| ACCESSION: | WOS:001001450800010 |
| DOI: | 10.1126/science.adg6425 |
| PROVIDER: | wos |
| PUBMED: | 37141369 |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding author is MSK author Chrysothemis C. Brown -- Source: Wos |
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