Prolonged generalized immune response on (18)F-FDG PET/CT following COVID-19 vaccination Journal Article

   


Authors: Sawant, D. A.; Razmaria, A. A.; Pandit-Taskar, N.
Article Title: Prolonged generalized immune response on (18)F-FDG PET/CT following COVID-19 vaccination
Abstract: The Coronavirus disease 2019 (COVID-19) pandemic continues to be a major public health concern affecting millions of people globally. The COVID-19 vaccination has implications in medical assessment of cancer patients especially undergoing diagnostic imaging such as 18F-fluoro-deoxyglucose (FDG) positron emission tomography with computed tomography (PET/CT). The inflammatory changes following vaccination can cause false positive findings on imaging. We present a case of a patient with esophageal carcinoma who had 18F-FDG PET/CT scan, 8 weeks following booster dose of Moderna COVID-19 vaccination, which showed widespread FDG avid reactive lymph nodes and intense splenic uptake for prolonged duration of approximately 8 months (34 weeks) probably representing generalized immune response. It is important from radiological/nuclear medicine perspective to recognize imaging features of such rare effect of COVID-19 vaccination, which can pose a challenge in assessing 18F-FDG PET/CT scans in cancer patients. It has also opened new avenues for future research evaluating such COVID-19 vaccine-related prolonged systemic immunological response in cancer patients. © 2023
Keywords: clinical article; aged; case report; spleen; inflammation; liver metastasis; immune response; lymph node; splenomegaly; vaccination; fluorodeoxyglucose f 18; esophageal adenocarcinoma; stomach adenocarcinoma; esophagus carcinoma; fdg; pet/ct; maximum standardized uptake value; nivolumab; regorafenib; human; male; article; interstitial nephritis; positron emission tomography-computed tomography; coronavirus disease 2019; covid-19; elasomeran
Journal Title: Radiology Case Reports
Volume: 18
Issue: 8
ISSN: 1930-0433
Publisher: Elsevier Inc.  
Date Published: 2023-08-01
Start Page: 2552
End Page: 2557
Language: English
DOI: 10.1016/j.radcr.2023.04.046
PROVIDER: scopus
PMCID: PMC10202611
PUBMED: 37250482
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159895676&doi=10.1016%2fj.radcr.2023.04.046&partnerID=40&md5=22b54f09bd4f28db35c937e2d9671fd6
Notes: Article -- Source: Scopus
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MSK Authors
  1. Neeta Pandit-Taskar
    345 Pandit-Taskar
  2. Ali Aria Razmaria
    7 Razmaria
  3. Devendra Arvind Sawant
    1 Sawant
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