Experimental proof of record-short coincidence time resolution performance achieved in 3×3×3 mm(3) LYSO crystals Conference Paper


Authors: Harmon, E. S.; Thompson, M. O.; Schmidtlein, C. R.; Turner, J. N.; Gola, A.; Borghi, G.; Merzi, S.; Moretti, E.; Krol, A.
Editors: Gimi, B. S.; Krol, A.
Title: Experimental proof of record-short coincidence time resolution performance achieved in 3×3×3 mm(3) LYSO crystals
Conference Title: Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging
Abstract: In this study, we re-evaluated the attainable coincidence time resolution (CTR) performance for 3×3×3 mm3 LYSO crystals coupled to matched 3×3 mm2 SiPMs. This work was motivated by potential increased sensitivity in brain positron emission tomography (PET) detector blocks that would be enabled with ultrashort CTR (<100 ps). The recent progress in silicon photomultiplier (SiPM) technology, high-frequency read-out circuits, and optimized data processing is expected to lead directly to improved performance. The 3×3×3 mm3 LYSO crystals, with all sides polished to optical quality, were optically coupled to SiPMs designed and fabricated by Fondazione Bruno Kessler (FBK). An improved high frequency read-out circuit was designed and fabricated. CTR was measured using a 22Na positron source (<10 μCi) sandwiched between two identical LYSO/SiPM/read-out circuit stacks. Our studies show that a CTR of less than 80 ps, which, to the best of our knowledge, is the shortest reported CTR for 3×3×3 mm3 LYSO crystals. The results demonstrate, for the first time, that CTR performance in 3×3×3 mm3 LYSO crystals coupled to a 3mm×3mm2 SiPMs is comparable to CTRs achieved for ultra-small LYSO crystals (2×2×3 mm3) coupled to large 4 × 4 mm2 SiPMs. These results prove that an array of 3×3×3 mm3 LYSO/SiPM can be used to build a next generation high performance detector block with very high packing fraction, enabling ultimately very high gamma ray detection efficiency and very high system sensitivity. © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.
Keywords: positron emission tomography; electrons; performance; positrons; silicon; gamma rays; photomultipliers; data handling; brain pet; coincidence timing resolution; timing resolutions; timing circuits; ctr; sipm; effective sensitivity gain; silicon photomultiplier; brain positron emission tomography; coincidence time resolution; lyso crystals; silicon photo multipliers (sipm); time-resolution
Journal Title Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume: 12468
Conference Dates: 2023 Feb 19-22
Conference Location: San Diego, CA
ISBN: 1605-7422
Publisher: SPIE  
Date Published: 2023-01-01
Start Page: 12468-14
Language: English
DOI: 10.1117/12.2656891
PROVIDER: scopus
DOI/URL:
Notes: Conference paper: 12468 0G -- Source: Scopus
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