Colorectal cancer: Review of signaling pathways and associated therapeutic strategies Review
| Authors: | Leiphrakpam, P. D.; Rajappa, S. J.; Krishnan, M.; Batra, R.; Murthy, S. S.; Are, C. |
| Review Title: | Colorectal cancer: Review of signaling pathways and associated therapeutic strategies |
| Abstract: | Tumor profiling and targeted therapy revolutionized the treatment strategies of metastatic colorectal cancer (mCRC) in the last decade. The heterogeneity of CRC tumors plays a critical role in the development of treatment resistance, which underscores the need to understand the molecular mechanism involved in CRC to develop novel targeted therapeutic strategies. This review provides an overview of the signaling pathways driving CRC, the existing targeted agents, their limitations, and future trends. © 2023 Wiley Periodicals LLC. |
| Keywords: | signal transduction; colorectal cancer; biomarkers; colonic neoplasms; colon tumor; targeted therapy; rectal neoplasms; rectum tumor; humans; human |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 127 |
| Issue: | 8 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2023-06-15 |
| Start Page: | 1277 |
| End Page: | 1295 |
| Language: | English |
| DOI: | 10.1002/jso.27295 |
| PUBMED: | 37222698 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Erratum issued, see DOI: 10.1002/jso.27374 -- Source: Scopus |
