Teclistamab versus real-world physician's choice of therapy in triple-class exposed relapsed/refractory multiple myeloma Journal Article
| Authors: | Krishnan, A.; Nooka, A. K.; Chari, A.; Garfall, A. L.; Martin, T. G.; Nair, S.; Lin, X.; Qi, K.; Londhe, A.; Pei, L.; Ammann, E.; Kobos, R.; Smit, J.; Parekh, T.; Marshall, A.; Slavcev, M.; Usmani, S. Z. |
| Article Title: | Teclistamab versus real-world physician's choice of therapy in triple-class exposed relapsed/refractory multiple myeloma |
| Abstract: | Aim: We compared the effectiveness of teclistamab versus real-world physician's choice of therapy (RWPC) in triple-class exposed relapsed/refractory multiple myeloma. Materials & methods: MajesTEC-1 eligibility criteria were applied to the RWPC cohort. Baseline covariate imbalances were adjusted using inverse probability of treatment weighting. Overall survival, progression-free survival and time to next treatment were compared. Results: After inverse probability of treatment weighting, baseline characteristics were similar between cohorts (teclistamab, n = 165; RWPC, n = 364 [766 observations]). Teclistamab treated patients had numerically better overall survival (hazard ratio [HR]: 0.82 [95% CI: 0.59-1.14]; p = 0.233) and significantly greater progression-free survival (HR: 0.43 [0.33-0.56]; p < 0.0001) and time to next treatment (HR: 0.36 [0.27-0.49]; p < 0.0001) versus the RWPC cohort. Conclusion: Teclistamab offered clinical benefit over RWPC in triple-class exposed relapsed/refractory multiple myeloma. |
| Keywords: | treatment outcome; antineoplastic agents; antineoplastic agent; multiple myeloma; antineoplastic combined chemotherapy protocols; dexamethasone; physicians; physician; comparative effectiveness; bispecific antibody; humans; human; b-cell maturation antigen; indirect treatment comparison; majestec-1 |
| Journal Title: | Journal of Comparative Effectiveness Research |
| Volume: | 12 |
| Issue: | 6 |
| ISSN: | 2042-6305 |
| Publisher: | Future Medicine |
| Date Published: | 2023-06-01 |
| Start Page: | e220186 |
| Language: | English |
| DOI: | 10.57264/cer-2022-0186 |
| PUBMED: | 37114426 |
| PROVIDER: | scopus |
| PMCID: | PMC10402759 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
