Mature B- and plasma-cell flow cytometric analysis: A review of the impact of targeted therapy Review

  


Authors: Gao, Q.; Chen, X.; Cherian, S.; Roshal, M.
Review Title: Mature B- and plasma-cell flow cytometric analysis: A review of the impact of targeted therapy
Abstract: Flow cytometry has been indispensable in diagnosing B cell lymphoma and plasma cell neoplasms. The advances in novel multicolor flow cytometry have also made this technology a robust tool for monitoring minimal/measurable residual disease in chronic lymphocytic leukemia and multiple myeloma. However, challenges using conventional gating strategies to isolate neoplastic B or plasma cells are emerging due to the rapidly increasing number of antibody therapeutics targeting single or multiple classic B/plasma cell-lineage markers, such as CD19, CD20, and CD22 in B cells and CD38 in plasma cells. This review is the first of a two-part series that summarizes the most current targeted therapies used in B and plasma cell neoplasms and proposes detailed alternative approaches to overcome post-targeted therapy analysis challenges by flow cytometry. The second review in this series (Chen et al.) focuses on challenges encountered in the use of targeted therapy in precursor B cell neoplasms. © 2022 International Clinical Cytometry Society.
Keywords: flow cytometry; multiple myeloma; plasmacytoma; pathology; b lymphocyte; b-lymphocytes; b cell lymphoma; plasma cell; minimal residual disease; neoplasm, residual; immunophenotyping; antigens, cd; neoplasms, plasma cell; leukocyte antigen; plasma cells; humans; human; minimal/measurable residual disease; targeted immunotherapy
Journal Title: Cytometry Part B—Clinical Cytometry
Volume: 104
Issue: 3
ISSN: 1552-4949
Publisher: Wiley Blackwell  
Date Published: 2023-05-01
Start Page: 224
End Page: 242
Language: English
DOI: 10.1002/cyto.b.22097
PUBMED: 36321879
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85141407899&doi=10.1002%2fcyto.b.22097&partnerID=40&md5=e0830180cf9ffa5ac62f93d2ed9900cd
Notes: Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Mikhail Roshal -- Export Date: 31 May 2023 -- Source: Scopus
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MSK Authors
  1. Mikhail Roshal
    235 Roshal
  2. Qi Gao
    68 Gao
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