Small volume biopsy diagnostic yield at initial diagnosis versus recurrence/transformation of follicular lymphoma: A retrospective Cyto-Heme Interinstitutional Collaborative study Journal Article
| Authors: | Fitzpatrick, M. J.; Sundaram, V.; Ly, A.; Abramson, J. S.; Balassanian, R.; Cheung, M. C.; Cook, S. L.; Falchi, L.; Frank, A. K.; Gupta, S.; Hasserjian, R. P.; Lin, O.; Long, S. R.; Menke, J. R.; Mou, E.; Reed, D. R.; Ruiz-Cordero, R.; Volaric, A. K.; Wang, L.; Wen, K. W.; Xie, Y.; Zadeh, S. L.; Gratzinger, D. |
| Article Title: | Small volume biopsy diagnostic yield at initial diagnosis versus recurrence/transformation of follicular lymphoma: A retrospective Cyto-Heme Interinstitutional Collaborative study |
| Abstract: | Background: Few studies have evaluated diagnostic yield of small volume biopsies (SVB) for the diagnosis and management of follicular lymphoma (FL). Methods: The authors performed a multi-institutional retrospective analysis of SVBs including fine-needle aspiration (FNA) and needle core biopsy (NCB) for initial FL diagnosis and suspected recurrence or transformation of FL. A total of 676 workups beginning with SVB were assessed for the mean number of biopsies per workup, the proportion of workups requiring multiple biopsies, and the proportion with a complete diagnosis including grade, on initial biopsy. Results: Compared to workups performed for question transformation/recurrence, those done for initial FL diagnosis were significantly more likely to require multiple biopsies (p <.01), had a higher mean number of biopsies per workup (1.7 vs. 1.1, absolute standardized difference = 1.1), and a lower complete diagnosis rate at initial biopsy (39% vs. 56%). At initial FL diagnosis, NCB +/− FNA was associated with fewer biopsies per workup compared to FNA +/− CB (1.2 vs. 1.9), fewer workups requiring multiple biopsies (23% vs. 83%), and a higher complete diagnosis rate (71% vs. 18%). In contrast, during assessment for transformation/recurrence, NCB and FNA showed a similar mean number of biopsies per workup (1.2 vs. 1.2) and few workups required multiple biopsies (6% vs. 19%). Conclusions: SVB at initial FL diagnosis often required additional biopsies to establish a complete diagnosis. In contrast, when assessing for transformed/recurrent FL, additional biopsies were generally not obtained regardless of SVB type, suggesting that in these clinical settings SVB may be sufficient for clinical decision-making. © 2022 The Authors. Cancer Cytopathology published by Wiley Periodicals LLC on behalf of American Cancer Society. |
| Keywords: | retrospective studies; pathology; retrospective study; biopsy, fine-needle; clinical decision making; follicular lymphoma; lymphoma, follicular; fine needle aspiration biopsy; fine-needle aspiration; clinical decision-making; biopsy, large-core needle; large core needle biopsy; humans; human; needle core biopsy; small volume biopsy |
| Journal Title: | Cancer Cytopathology |
| Volume: | 131 |
| Issue: | 5 |
| ISSN: | 1934-662X |
| Publisher: | John Wiley & Sons |
| Date Published: | 2023-05-01 |
| Start Page: | 279 |
| End Page: | 288 |
| Language: | English |
| DOI: | 10.1002/cncy.22676 |
| PUBMED: | 36573933 |
| PROVIDER: | scopus |
| PMCID: | PMC10557381 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Source: Scopus |
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