Clinical outcomes in vitrectomized versus non-vitrectomized eyes in patients with primary vitreoretinal lymphoma Journal Article
| Authors: | Liberman, P.; Francis, J. H.; Mehrotra, K.; Tian, J.; McGarrey, M. P.; Sobol, E. K.; Thorne, J. E.; Aronow, M. E.; Berkenstock, M. K. |
| Article Title: | Clinical outcomes in vitrectomized versus non-vitrectomized eyes in patients with primary vitreoretinal lymphoma |
| Abstract: | Aim: To evaluate if there is a difference in the clinical course of primary vitreoretinal lymphoma (PVRL) in vitrectomized versus non-vitrectomized eyes. Methods: Observational multicenter retrospective case series of patients diagnosed with PVRL between 2007 and 2019, at three tertiary centers. The main outcomes were relapse rates, inflammatory parameters, and best-corrected visual acuities (BCVA). Statistical methods used were an adjusted generalized estimating equation model, and a proportional Cox model. Results: Eighty patients (150 eyes) were followed for a median of 1.7 years. At presentation, there were no clinical differences between the groups. The relapse rate was 0.091/eye-year (EY) for vitrectomized eyes and 0.087/EY for non-vitrectomized eyes (p = .35). Vitrectomized eyes had better BCVA than non-vitrectomized eyes (p < .001). Conclusions: Vitrectomy had no effect on the relapse rate in eyes with PVRL. However, the decrease in vitreous cell and debris led to vitrectomized eyes having better visual acuity than non-vitrectomized eyes. © 2022 Taylor & Francis Group, LLC. |
| Keywords: | adult; cancer chemotherapy; controlled study; aged; retrospective studies; major clinical study; clinical trial; disease course; cancer recurrence; cancer radiotherapy; methotrexate; recurrence risk; follow up; antineoplastic agent; neoplasm recurrence, local; retina tumor; retinal neoplasms; retrospective study; nonhodgkin lymphoma; multicenter study; tumor recurrence; lymphoma; intraocular pressure; observational study; ocular lymphoma; optical coherence tomography; vitreous body; clinical outcome; macular edema; vitrectomy; humans; human; male; female; article; best corrected visual acuity; primary vitreoretinal lymphoma; central macular thickness |
| Journal Title: | Ocular Immunology and Inflammation |
| Volume: | 31 |
| Issue: | 3 |
| ISSN: | 0927-3948 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2023-01-01 |
| Start Page: | 496 |
| End Page: | 500 |
| Language: | English |
| DOI: | 10.1080/09273948.2022.2033794 |
| PUBMED: | 35201943 |
| PROVIDER: | scopus |
| PMCID: | PMC10392775 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 May 2023 -- Source: Scopus |
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