Development of a novel measure of advanced cancer patients’ perceived utility of secondary germline findings from tumor genomic profiling Journal Article


Authors: Hamilton, J. G.; Shah, I. H.; Salafia, C.; Schofield, E.; Garzon, M. G.; Cadet, K.; Stadler, Z. K.; Hay, J. L.; Offit, K.; Robson, M. E.
Article Title: Development of a novel measure of advanced cancer patients’ perceived utility of secondary germline findings from tumor genomic profiling
Abstract: Objective: Tumor genomic profiling (TGP) can inform advanced cancer patients’ treatment decisions, and also reveal secondary germline findings—information about inherited risks for cancer and other disorders. We sought to develop a measure of patient perceptions of the clinical and personal utility of secondary germline findings. Methods: We developed a draft survey based on literature and patient interview data (n=40). We evaluated and refined the survey through cognitive interviews with advanced cancer patients who received secondary germline findings from TGP (n=10). The survey was psychometrically validated with data from two independent samples of advanced cancer patients undergoing TGP (total n=349). Results: Cognitive interviews offered opportunities for survey refinement and confirmation of its comprehensible nature. Exploratory and confirmatory factor analysis of the survey identified 16 items across three subscales with strong internal consistency (Cronbach's alpha ≥0.79): perceived utility for others, perceived utility for self and health, and confidence in secondary findings. Conclusion: We developed a novel valid scale with promise for measuring advanced cancer patients’ perceptions of the utility of secondary germline findings. Innovation: We offer a new patient-derived measure of perceived utility of and confidence in secondary germline findings with potential applications for precision oncology research and clinical communication. © 2023 The Authors
Keywords: oncology; genetic testing; genomic sequencing; perceived utility; incidental germline findings; secondary germline findings; tumor-normal analysis
Journal Title: PEC Innovation
Volume: 2
ISSN: 2772-6282
Publisher: Elsevier BV  
Date Published: 2023-12-01
Start Page: 100124
Language: English
DOI: 10.1016/j.pecinn.2023.100124
PROVIDER: scopus
PMCID: PMC10194097
PUBMED: 37214538
DOI/URL:
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Jada G. Hamilton -- Source: Scopus
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MSK Authors
  1. Kenneth Offit
    791 Offit
  2. Mark E Robson
    682 Robson
  3. Zsofia Kinga Stadler
    395 Stadler
  4. Jennifer L Hay
    269 Hay
  5. Margaux Christine Genoff
    24 Genoff
  6. Jada Gabrielle Hamilton
    113 Hamilton
  7. Elizabeth A Schofield
    164 Schofield
  8. Kechna Cadet
    3 Cadet
  9. Ibrahim Hussein Shah
    8 Shah