The bridging conundrum: Perioperative management of direct oral anticoagulants for venous thromboembolism Review


Authors: Berry, J.; Patell, R.; Zwicker, J. I.
Review Title: The bridging conundrum: Perioperative management of direct oral anticoagulants for venous thromboembolism
Abstract: Most patients diagnosed with venous thromboembolism (VTE) are currently treated with direct oral anticoagulants (DOACs). Before an invasive procedure or surgery, clinicians face the challenging decision of how to best manage DOACs. Should the DOAC be held, for how long, and are there instances where bridging with other anticoagulants should be considered? Although clinical trials indicate that most patients taking DOACs for atrial fibrillation do not require bridging anticoagulation, the optimal strategy for patients with a history of VTE is undefined. In this review, we present a case-based discussion for DOAC interruption perioperatively in patients receiving anticoagulation for management of VTE. © 2022
Keywords: clinical article; aged; debridement; case report; advanced cancer; recurrence risk; infection; bleeding; risk assessment; backache; lung embolism; lung adenocarcinoma; conservative treatment; prophylaxis; echography; anticoagulants; warfarin; single drug dose; anticoagulation; administration, oral; thorax surgery; atrial fibrillation; oral contraceptive agent; leg pain; enoxaparin; low molecular weight heparin; low back pain; venous thromboembolism; anticoagulant agent; apixaban; rivaroxaban; oral drug administration; spine surgery; perioperative care; blood clotting; blood coagulation; thrombus; medical history; hemorrhage; wedge resection; leg swelling; orthopedic surgeon; traffic accident; femoral vein; abdominal wall defect; humans; procedure; human; male; female; article; hip osteoarthritis; treatment interruption; total hip replacement; popliteal vein; perioperative medicine; direct-acting oral anticoagulants; bridging anticoagulation
Journal Title: Journal of Thrombosis and Haemostasis
Volume: 21
Issue: 4
ISSN: 1538-7933
Publisher: Wiley Blackwell  
Date Published: 2023-04-01
Start Page: 780
End Page: 786
Language: English
DOI: 10.1016/j.jtha.2022.12.024
PUBMED: 36709100
PROVIDER: scopus
DOI/URL:
Notes: Article -- MSK corresponding author is Jeffrey Zwicker -- Export Date: 1 May 2023 -- Source: Scopus
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  1. Jeffrey Zwicker
    35 Zwicker